IONIS PHARMACEUTICALS INC — Director's Dealing 2019

Feb 5, 2019

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: IONIS PHARMACEUTICALS INC (IONS)
CIK: 0000874015
Period of Report: 2019-02-01

Reporting Person: O'NEIL PATRICK R. (SVP Legal & General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2019-02-01	Common Stock	M	4000	$39.87	Acquired	23673	Direct
2019-02-01	Common Stock	S	4000	$58.29	Disposed	19673	Direct
2019-02-05	Common Stock	M	15600	$39.87	Acquired	35273	Direct
2019-02-05	Common Stock	S	15600	$59.50	Disposed	19673	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2019-02-01	Employee Stock Option (right to buy)	$39.87	M	4000	Acquired	2021-01-01	Common Stock (4000)	Direct
2019-02-05	Employee Stock Option (right to buy)	$39.87	M	15600	Acquired	2021-01-01	Common Stock (15600)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.