IONIS PHARMACEUTICALS INC — Director's Dealing 2018

Jan 29, 2018

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: IONIS PHARMACEUTICALS INC (IONS)
CIK: 0000874015
Period of Report: 2018-01-25

Reporting Person: O'NEIL PATRICK R. (SVP Legal & General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2018-01-25	Common Stock	M	645	$10.82	Acquired	15097	Direct
2018-01-25	Common Stock	S	645	$55.00	Disposed	14452	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2018-01-25	Employee Stock Option (right to buy)	$10.82	M	645	Disposed	2020-01-01	Common Stock (645)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.