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IONIS PHARMACEUTICALS INC Director's Dealing 2018

May 31, 2018

30591_dirs_2018-05-31_f4e0678d-31e0-49d3-be2a-7097766689a8.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: IONIS PHARMACEUTICALS INC (IONS)
CIK: 0000874015
Period of Report: 2018-05-31

Reporting Person: MUTO FREDERICK T (Director)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2018-05-31 Common Stock M 15000 $13.88 Acquired 22127 Direct
2018-05-31 Common Stock S 15000 $46.45 Disposed 7127 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2018-05-31 Non-Employee Director Stock Option $13.88 M 15000 Disposed 2018-06-30 Common Stock (15000) Direct

Holdings (Non-Derivative)

Security Shares Ownership
Common Stock 1500 Indirect

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015.

F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $46.25 to $46.60, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.