IONIS PHARMACEUTICALS INC — Director's Dealing 2018

Aug 9, 2018

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: IONIS PHARMACEUTICALS INC (IONS)
CIK: 0000874015
Period of Report: 2018-08-08

Reporting Person: BENNETT C FRANK (SVP, Antisense Research)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2018-08-08	Common Stock	M	13	$7.25	Acquired	19409	Direct
2018-08-08	Common Stock	S	13	$45.00	Disposed	19396	Direct
2018-08-08	Common Stock	M	12487	$14.69	Acquired	31883	Direct
2018-08-08	Common Stock	S	12487	$45.00	Disposed	19396	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2018-08-08	Employee Stock Option (right to buy)	$7.25	M	13	Acquired	2019-01-02	Common Stock (13)	Direct
2018-08-08	Employee Stock Option (right to buy)	$14.69	M	12487	Acquired	2020-01-29	Common Stock (12487)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.