IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Mar 9, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-03-05

Reporting Person: O'NEIL PATRICK R. (SVP, Legal & General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-03-05	Common Stock	M	1667	$8.00	Acquired	7841	Direct
2015-03-05	Common Stock	S	1667	$71.668	Disposed	6174	Direct
2015-03-05	Common Stock	M	4133	$10.29	Acquired	10307	Direct
2015-03-05	Common Stock	S	4133	$71.668	Disposed	6174	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-03-05	Employee Stock Option (right to buy)	$8.00	M	1667	Disposed	2017-08-31	Common Stock (1667)	Direct
2015-03-05	Employee Stock Option (right to buy)	$10.29	M	4133	Disposed	2018-01-02	Common Stock (4133)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 2/3/2015.