IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Apr 8, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-04-07

Reporting Person: CROOKE STANLEY T (Director, Chairman and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-04-07	Common Stock	M	20343	$11.27	Acquired	34985	Direct
2015-04-07	Common Stock	S	20343	$63.071	Disposed	14642	Direct
2015-04-07	Common Stock	M	2034	$9.22	Acquired	3331	Indirect
2015-04-07	Common Stock	S	2034	$63.071	Disposed	1297	Indirect

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-04-07	Employee Stock Option (right to buy)	$11.27	M	20343	Disposed	2017-01-03	Common Stock (20343)	Direct
2015-04-07	Employee Stock Option (right to buy)	$9.22	M	2034	Disposed	2017-07-18	Common Stock (2034)	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	725391	Indirect

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/6/2013.

F2: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 8/6/2013.