IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Jul 2, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-07-01

Reporting Person: PARSHALL B LYNNE (Director, COO & Secretary)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-07-01	Common Stock	J	71	$48.586	Acquired	8143	Direct
2015-07-01	Common Stock	M	6218	$10.29	Acquired	14361	Direct
2015-07-01	Common Stock	S	6218	$57.561	Disposed	8143	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-07-01	Employee Stock Option (right to buy)	$10.29	M	6218	Disposed	2018-01-02	Common Stock (6218)	Direct

Footnotes

F1: Reporting 71 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2015. These 71 shares may not be sold until January 2, 2016.

F2: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/11/2015.