IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Nov 12, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-11-10

Reporting Person: BENNETT C FRANK (SVP, Antisense Research)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-11-10	Common Stock	M	5000	$14.47	Acquired	12316	Direct
2015-11-10	Common Stock	S	5000	$64.00	Disposed	7316	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-11-10	Employee Stock Option (right to buy)	$14.47	M	5000	Disposed	2016-01-01	Common Stock (5000)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/16. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/20/2015.