IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Jan 5, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-01-01

Reporting Person: Boyce Sarah (Chief Business Officer)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-01-01	Employee Stock Option (right to buy)	$61.74	A	52500	Acquired	2021-12-31	Common Stock (52500)	Direct

Footnotes

F1: Grant of 1/1/2015 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/1/2016. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 13,125 shares per year. The option was exercisable as to 0 on 1/1/2015.