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IONIS PHARMACEUTICALS INC Director's Dealing 2015

Jan 5, 2015

30591_dirs_2015-01-05_d96693c4-4858-4848-ab28-a41569da8eb1.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-01-01

Reporting Person: Geary Richard S (SVP, Development)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2015-01-01 Common Stock J 273 $30.0475 Acquired 5661 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2015-01-02 Employee Stock Option (right to buy) $61.57 A 33112 Acquired 2022-01-01 Common Stock (33112) Direct

Footnotes

F1: Reporting 273 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2015. These 273 shares may not be sold until July 2, 2015.

F2: Grant of 1/2/2015 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2016. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 8,278 shares per year. The option was exercisable as to 0 on 1/2/2015.