IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Jul 2, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-07-01

Reporting Person: O'NEIL PATRICK R. (SVP, Legal & General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-07-01	Common Stock	J	85	$48.586	Acquired	6259	Direct

Footnotes

F1: Reporting 85 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2015. These 85 shares may not be sold until January 2, 2016.