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IONIS PHARMACEUTICALS INC Director's Dealing 2015

Feb 17, 2015

30591_dirs_2015-02-17_4906c668-63a9-4d55-8fab-8c045c143c69.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-02-12

Reporting Person: WENDER JOSEPH H (Director)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2015-02-12 Common Stock M 10000 $3.95 Acquired 47217 Indirect
2015-02-12 Common Stock S 10000 $62.146 Disposed 37217 Indirect

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2015-02-12 Non-Employee Director Stock Option (right to buy) $3.95 M 10000 Disposed 2015-06-30 Common Stock (10000) Indirect

Footnotes

F1: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2015.

F2: The sale was a result of shares owned. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.960 to $62.325, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.