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IONIS PHARMACEUTICALS INC Director's Dealing 2015

Jan 5, 2015

30591_dirs_2015-01-05_d2448796-eea7-4beb-85fb-08a2a83e8798.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-01-01

Reporting Person: PARSHALL B LYNNE (Director, COO & Secretary)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2015-01-01 Common Stock J 111 $30.0475 Acquired 4417 Direct
2015-01-02 Common Stock M 11200 $14.69 Acquired 15617 Direct
2015-01-02 Common Stock S 11200 $62.115 Disposed 4417 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2015-01-02 Employee Stock Option (right to buy) $61.57 A 132458 Acquired 2022-01-01 Common Stock (132458) Direct
2015-01-02 Employee Stock Option (right to buy) $14.69 M 11200 Disposed 2020-01-29 Common Stock (11200) Direct

Footnotes

F1: Reporting 111 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2015. These 111 shares may not be sold until July 2, 2015.

F2: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 7/29/2014.

F3: Grant of 1/2/2015 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2016. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 33,115 shares per year. The option was exercisable as to 0 on 1/2/2015.

F4: Grant of 1/30/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,570 shares per year. Following this transaction, the option was exercisable as to 17,430 on 1/2/2015.