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IONIS PHARMACEUTICALS INC Director's Dealing 2014

Jan 24, 2014

30591_dirs_2014-01-24_f7fce4c6-101b-4bc5-bea2-7907226460e5.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-01-24

Reporting Person: KLEIN JOSEPH III (Director)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2014-01-24 Common Stock M 7500 $16.32 Acquired 9813 Direct
2014-01-24 Common Stock S 7500 $48.6797 Disposed 2313 Direct
2014-01-24 Common Stock M 2813 $12.94 Acquired 5126 Direct
2014-01-24 Common Stock S 2813 $48.6102 Disposed 2313 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2014-01-24 Director Stock Option (right to buy) $16.32 M 7500 Disposed 2019-06-30 Common Stock (7500) Direct
2014-01-24 Director Stock Option (right to buy) $12.94 M 2813 Disposed 2022-07-01 Common Stock (2813) Direct

Footnotes

F1: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.75 to $48.62, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4.

F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.60 to $48.62, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4.

F3: Grant of 7/2/12 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vestong on 7/2/13. The option shall be fully vested and exercisable on 7/2/16. Following the reported option exercise, the option was exercisable as to 0 shares on 1/24/14.