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IONIS PHARMACEUTICALS INC Director's Dealing 2014

Oct 31, 2014

30591_dirs_2014-10-31_24953b9f-dbdf-456d-bd5e-0f29bdb260fb.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-10-30

Reporting Person: PARSHALL B LYNNE (Director, COO & Secretary)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2014-10-30 Common Stock M 2510 $14.69 Acquired 6816 Direct
2014-10-30 Common Stock S 2510 $45.121 Disposed 4306 Direct
2014-10-30 Common Stock M 8561 $7.25 Acquired 12867 Direct
2014-10-30 Common Stock S 8561 $45.121 Disposed 4306 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2014-10-30 Employee Stock Option (right to buy) $14.69 M 2510 Disposed 2020-01-29 Common Stock (2510) Direct
2014-10-30 Employee Stock Option (right to buy) $7.25 M 8561 Disposed 2019-01-02 Common Stock (8561) Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 7/29/2014.

F2: Grant of 1/30/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,570 shares per year. Following this transaction, the option was exercisable as to 24,737 on 10/30/14.

F3: Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,437 shares per year. Following this transaction, the option was exercisable as to 2,573 on 10/30/2014.