IONIS PHARMACEUTICALS INC — Director's Dealing 2014

Jul 1, 2014

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-07-01

Reporting Person: PARSHALL B LYNNE (Director, COO & Secretary)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2014-07-01	Common Stock	J	284	$30.2005	Acquired	4306	Direct

Footnotes

F1: Reporting 284 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2014. These 284 shares may not be sold until January 2, 2015.