IONIS PHARMACEUTICALS INC — Director's Dealing 2014

Oct 28, 2014

SEC Form 4/A — Form 4/A

Issuer: Regulus Therapeutics Inc. (RGLS)
CIK: 0001505512
Period of Report: 2014-10-22

Reporting Person: ISIS PHARMACEUTICALS INC (Director, 10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2014-10-22	Common Stock	S	9283	$12.1792	Disposed	6899517	Direct
2014-10-22	Common Stock	S	15791	$12.8309	Disposed	6883726	Direct
2014-10-22	Common Stock	S	57753	$13.9112	Disposed	6825973	Direct
2014-10-22	Common Stock	S	15156	$14.6707	Disposed	6810817	Direct
2014-10-22	Common Stock	S	11376	$16.5881	Disposed	6799441	Direct
2014-10-22	Common Stock	S	175	$17.11	Disposed	6799266	Direct
2014-10-23	Common Stock	S	1200	$13.939	Disposed	6798066	Direct
2014-10-23	Common Stock	S	450	$14.8956	Disposed	6797616	Direct
2014-10-23	Common Stock	S	50	$15.45	Disposed	6797566	Direct
2014-10-24	Common Stock	S	1054	$14.6277	Disposed	6796512	Direct
2014-10-24	Common Stock	S	350	$15.5014	Disposed	6796162	Direct
2014-10-24	Common Stock	S	446	$16.2922	Disposed	6795716	Direct

Footnotes

F1: The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 22, 2014.

F2: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.47 to $12.47 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F3: The shares are held directly by Isis Pharmaceuticals, Inc. Ms. Parshall is an officer and director of Isis and therefore may be deemed to have voting or investment power over the shares beneficially owned by Isis. Ms. Parshall disclaims beneficial ownership over the shares beneficially owned by Isis, except to the extent of her proportionate pecuniary interest therein as a stockholder of Isis.

F4: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.48 to $13.44 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F5: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.47 to $14.47 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F6: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.48 to $15.27 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F7: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $17.00 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F8: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed.

F9: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.30 to $14.27 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F10: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.42 to $15.30 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F11: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed.

F12: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.12 to $15.02 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F13: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.23 to $15.71 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

F14: This Form 4 is being amended to itemize the sales prices which were not available at the time the Form 4 was originally filed. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.29 to $16.31 inclusive. The reporting person undertakes to provide to RGLS, any security holder of RGLS, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.