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IONIS PHARMACEUTICALS INC Director's Dealing 2014

Mar 5, 2014

30591_dirs_2014-03-05_b28b44cc-3884-49ab-a858-8f45ff359522.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-03-03

Reporting Person: O'NEIL PATRICK R. (SVP, Legal & General Counsel)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2014-03-03 Common Stock M 370 $11.27 Acquired 3720 Direct
2014-03-03 Common Stock S 370 $49.20 Disposed 3350 Direct
2014-03-03 Common Stock M 330 $10.82 Acquired 3680 Direct
2014-03-03 Common Stock S 330 $49.20 Disposed 3350 Direct
2014-03-03 Common Stock M 800 $10.82 Acquired 4150 Direct
2014-03-03 Common Stock S 800 $50.70 Disposed 3350 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2014-03-03 Employee Stock Option (right to buy) $11.27 M 370 Disposed 2017-01-03 Common Stock (370) Direct
2014-03-03 Employee Stock Option (right to buy) $10.82 M 1130 Disposed 2020-01-01 Common Stock (1130) Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 1/2/14.

F2: Grant of 1/4/10 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/4/11. Thereafter, the remaining shares subject to the option vest and become exercisalbe in 36 equal monthly installments, at the rate of 4,350 shares per year. Following this transaction, the option was exercisable as to 0 on 3/3/14.

F3: Grant of 1/2/13 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/14. Thereafter, the remaining shares subject to the option vest and become exercisalbe in 36 equal monthly installments, at the rate of 3,925 shares per year. Following this transaction, the option was exercisable as to 3,449 on 3/3/14.