IONIS PHARMACEUTICALS INC — Director's Dealing 2014

Jun 25, 2014

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-06-23

Reporting Person: BENNETT C FRANK (SVP, Antisense Research)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2014-06-23	Common Stock	M	6200	$15.38	Acquired	10536	Direct
2014-06-23	Common Stock	S	6200	$36.967	Disposed	4336	Direct
2014-06-23	Common Stock	M	5000	$15.38	Acquired	9336	Direct
2014-06-23	Common Stock	S	5000	$36.543	Disposed	4336	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2014-06-23	Employee Stock Option (right to buy)	$15.38	M	11200	Disposed	2015-01-01	Common Stock (11200)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/15. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 5/22/14.