IONIS PHARMACEUTICALS INC — Director's Dealing 2014

Jul 2, 2014

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2014-07-01

Reporting Person: LOSCALZO JOSEPH (Director)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2014-07-01	Restricted Stock Units	$	A	2667	Acquired		Common Stock (2667)	Direct
2014-07-01	Director Stock Option (right to buy)	$35.53	A	16000	Acquired	2024-06-30	Common Stock (16000)	Direct

Footnotes

F1: Each Restricted Stock Unit represents a contingent right to receive one share of Isis common stock, or its equivalent cash value.

F2: Grant of July 1, 2014 to reporting person of stock options under the Amended and Restated Isis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2015. The option shall be fully vested and exercisable on July 1, 2018. The option is exercisable as to 0 shares on July 1, 2014.

F3: Grant of July 1, 2014 to reporting person of stock options under the Amended and Restated Isis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2015. The option shall be fully vested and exercisable on July 1, 2018. The option is exercisable as to 0 shares on July 1, 2014.