IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Jul 9, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-07-05

Reporting Person: CROOKE STANLEY T (Director, Chairman and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-07-05	Common Stock	M	24180	$15.38	Acquired	25841	Direct
2013-07-05	Common Stock	S	24180	$30.015	Disposed	1661	Direct
2013-07-08	Common Stock	M	5008	$15.38	Acquired	6669	Direct
2013-07-08	Common Stock	S	5008	$30.026	Disposed	1661	Direct
2013-07-08	Common Stock	S	24992	$15.38	Acquired	26653	Direct
2013-07-08	Common Stock	S	24992	$30.09	Disposed	1661	Direct
2013-07-09	Common Stock	M	30000	$15.38	Acquired	31661	Direct
2013-07-09	Common Stock	S	30000	$30.043	Disposed	1661	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-07-05	Employee Stock Option (right to buy)	$15.38	M	24180	Disposed	2015-01-01	Common Stock (24180)	Direct
2013-07-08	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct
2013-07-09	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	775391	Indirect
Common Stock	174	Indirect

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/4/13.