IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Jul 3, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-07-01

Reporting Person: Monia Brett P (SVP, Antisense Drug Discovery)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-07-01	Common Stock	J	362	$9.197	Acquired	6057	Direct
2013-07-02	Common Stock	S	215	$28.6949	Disposed	5842	Direct

Footnotes

F1: Reporting 362 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2013. These 362 share may not be sold until January 2, 2014.

F2: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 10/24/2011.