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IONIS PHARMACEUTICALS INC Director's Dealing 2013

Feb 20, 2013

30591_dirs_2013-02-20_f8cb5091-2156-4019-8487-7695f569c92d.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-02-15

Reporting Person: O'NEIL PATRICK R. (SVP, Legal & General Counsel)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2013-02-15 Common Stock M 100 $10.29 Acquired 1424 Direct
2013-02-15 Common Stock S 100 $14.80 Disposed 1324 Direct
2013-02-15 Common Stock M 250 $10.29 Acquired 1574 Direct
2013-02-15 Common Stock S 250 $14.82 Disposed 1324 Direct
2013-02-19 Common Stock M 1600 $10.29 Acquired 2924 Direct
2013-02-19 Common Stock S 1600 $14.80 Disposed 1324 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2013-02-15 Employee Stock Option (right to buy) $10.29 M 100 Disposed 2018-01-02 Common Stock (100) Direct
2013-02-15 Employee Stock Option (right to buy) $10.29 M 250 Disposed 2018-01-02 Common Stock (250) Direct
2013-02-19 Employee Stock Option (right to buy) $10.29 M 1600 Disposed 2018-01-02 Common Stock (1600) Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 30, 2013.

F2: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 30, 2013.

F3: Grant of 1/3/2011 to reporting person of stock options under the Isis Pharamceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2012. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 5,750 shares per year. The option was exercisable as to 5,629 shares on 2/15/2013.

F4: Grant of 1/3/2011 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2012. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 5,750 shares per year. The option was exercisable as to 4,029 shares on 2/19/2013.