IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Mar 22, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-03-21

Reporting Person: Geary Richard S (Sr VP, Development)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-03-21	Common Stock	M	1000	$11.12	Acquired	5254	Direct
2013-03-21	Common Stock	S	1000	$19.50	Disposed	4254	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-03-21	Employee Stock Option (right to buy)	$11.12	M	1000	Disposed	2014-01-01	Common Stock (1000)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 10/14/2010.