IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Jun 13, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-06-11

Reporting Person: Monia Brett P (SVP, Antisense Drug Discovery)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-06-11	Common Stock	M	9375	$15.75	Acquired	15070	Direct
2013-06-11	Common Stock	S	9375	$23.76	Disposed	5695	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-06-11	Employee Stock Option (right to buy)	$15.75	M	9375	Disposed	2014-12-31	Common Stock (9375)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 10/24/2011.