IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Jul 12, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-07-10

Reporting Person: CROOKE STANLEY T (Director, Chairman and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-07-10	Common Stock	M	30000	$15.38	Acquired	31661	Direct
2013-07-10	Common Stock	S	30000	$30.048	Disposed	1661	Direct
2013-07-11	Common Stock	M	30000	$15.38	Acquired	311661	Direct
2013-07-11	Common Stock	S	30000	$32.003	Disposed	1661	Direct
2013-07-12	Common Stock	M	6000	$15.38	Acquired	7661	Direct
2013-07-12	Common Stock	S	6000	$32.83	Disposed	1661	Direct
2013-07-12	Common Stock	M	12000	$11.12	Acquired	13661	Direct
2013-07-12	Common Stock	S	12000	$33.084	Disposed	1661	Direct
2013-07-12	Common Stock	M	12000	$11.12	Acquired	13661	Direct
2013-07-12	Common Stock	S	12000	$33.5008	Disposed	1661	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-07-10	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct
2013-07-11	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct
2013-07-12	Employee Stock Option (right to buy)	$15.38	M	6000	Disposed	2015-01-01	Common Stock (6000)	Direct
2013-07-12	Employee Stock Option (right to buy)	$11.12	M	24000	Disposed	2014-01-01	Common Stock (24000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	775391	Indirect
Common Stock	174	Indirect

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/4/13.

F2: Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/2014. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/27/12.