IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Sep 11, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-09-09

Reporting Person: PARSHALL B LYNNE (Director, COO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-09-09	Common Stock	M	30000	$15.38	Acquired	32941	Direct
2013-09-09	Common Stock	S	30000	$30.415	Disposed	2941	Direct
2013-09-10	Common Stock	M	30000	$15.38	Acquired	32941	Direct
2013-09-10	Common Stock	S	30000	$31.648	Disposed	2941	Direct
2013-09-11	Common Stock	M	1520	$15.38	Acquired	4461	Direct
2013-09-11	Common Stock	S	1520	$31.181	Disposed	2941	Direct
2013-09-11	Common Stock	S	1985	$31.181	Disposed	956	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-09-09	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct
2013-09-10	Employee Stock Option (right to buy)	$15.38	M	30000	Disposed	2015-01-01	Common Stock (30000)	Direct
2013-09-11	Employee Stock Option (right to buy)	$15.38	M	1520	Disposed	2015-01-01	Common Stock (1520)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 8/6/2013.

F2: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 8/6/2013.