IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Jul 3, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-07-01

Reporting Person: Geary Richard S (SVP, Development)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-07-01	Common Stock	J	817	$9.197	Acquired	5071	Direct
2013-07-03	Common Stock	M	5000	$19.08	Acquired	10071	Direct
2013-07-03	Common Stock	S	5000	$29.02	Disposed	5071	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-07-03	Employee Stock Option (right to buy)	$19.08	M	5000	Disposed	2015-08-15	Common Stock (5000)	Direct

Footnotes

F1: Reporting 817 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2013. These 817 share may not be sold until January 2, 2014.

F2: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/12/13.