IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Sep 23, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-09-19

Reporting Person: BENNETT C FRANK (SVP, Antisense Research)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-09-19	Common Stock	M	10000	$15.38	Acquired	12866	Direct
2013-09-19	Common Stock	S	10000	$35.02	Disposed	2866	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-09-19	Employee Stock Option (right to buy)	$15.38	M	10000	Disposed	2015-01-01	Common Stock (10000)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 8/12/2013.