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IONIS PHARMACEUTICALS INC Director's Dealing 2013

Jul 3, 2013

30591_dirs_2013-07-03_82e6f119-2d0f-483f-82a8-60a3bec10804.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-07-01

Reporting Person: BERTHELSEN SPENCER R (Director)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2013-07-02 Common Stock M 313 Acquired 39613 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2013-07-01 Director Stock Option (right to buy) $28.47 A 11250 Acquired 2023-06-30 Common Stock (11250) Direct
2013-07-01 Restricted Stock Units $ A 1875 Acquired Common Stock (1875) Direct
2013-07-02 Restricted Stock Units $ M 313 Disposed Common Stock (313) Direct

Holdings (Non-Derivative)

Security Shares Ownership
Common Stock 70 Indirect

Footnotes

F1: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on July 2, 2012.

F2: Grant of 7/1/13 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2002 Non Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on 7/1/14. The option shall be fully vested and exercisable on 7/1/17. The option is exercisable as to 0 shares on 7/1/13.

F3: Each restricted stock unit represents a contingent right to receive one share of Isis common stock, or its equivalent cash value.

F4: The restricted stock units vest in four equal annual installments, the first installment vesting on 7/1/14. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on 7/1/17. The RSU is vested as to 0 shares on 7/1/13.

F5: Restricted Stock Unit Award granted on 7/2/12. Restricted Stock Units vest in equal annual installments, the first installment vested on 7/2/13. Upon vesting, the restricted stock units will be paid out in whole shares of Isis Common Stock or cash as may be determined by the Company. The RSU will be fully vested on 7/2/16.