IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Dec 30, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-12-26

Reporting Person: PARSHALL B LYNNE (Director, COO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-12-26	Common Stock	M	37811	$11.27	Acquired	38767	Direct
2013-12-26	Common Stock	S	37811	$40.908	Disposed	956	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-12-26	Employee Stock Option (right to buy)	$11.27	M	37811	Disposed	2017-01-03	Common Stock (37811)	Direct

Footnotes

F1: The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 11/22/13.