IONIS PHARMACEUTICALS INC — Director's Dealing 2013

Sep 23, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2013-09-19

Reporting Person: CROOKE STANLEY T (Director, Chairman and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-09-19	Common Stock	M	20000	$11.12	Acquired	21661	Direct
2013-09-19	Common Stock	S	20000	$35.124	Disposed	1661	Direct
2013-09-19	Common Stock	M	30000	$11.12	Acquired	31661	Direct
2013-09-19	Common Stock	S	30000	$35.02	Disposed	1661	Direct
2013-09-20	Common Stock	M	8740	$11.12	Acquired	10401	Direct
2013-09-20	Common Stock	S	8740	$35.898	Disposed	1661	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-09-19	Employee Stock Option (right to buy)	$11.12	M	50000	Disposed	2014-01-01	Common Stock (50000)	Direct
2013-09-20	Employee Stock Option (right to buy)	$11.12	M	8740	Disposed	2014-01-01	Common Stock (8740)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	174	Indirect
Common Stock	725391	Indirect

Footnotes

F1: Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/14. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/27/2012.