IONIS PHARMACEUTICALS INC — Director's Dealing 2011

Oct 24, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2011-10-24

Reporting Person: PARSHALL B LYNNE (Director, Director, COO)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-10-24	Employee Stock Option (right to buy)	$6.84	G	20000	Disposed	2013-01-01	Common Stock (20000)	Direct
2011-10-24	Employee Stock Option (right to buy)	$6.84	G	10000	Acquired	2013-01-01	Common Stock (10000)	Indirect
2011-10-24	Employee Stock Option (right to buy)	$6.84	G	10000	Acquired	2013-01-01	Common Stock (10000)	Indirect

Footnotes

F1: The reporting person transfrerred options to her two daughters who share reporting person's household, divided equally.