INVION LIMITED — Capital/Financing Update 2011

Sep 4, 2011

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5 September 2011

Dear Shareholder,

Non-renounceable Rights Issue- Ineligible Shareholders

CBio Limited (ASX: CBZ ) today lodged with the ASX a Rights Prospectus for a non-renounceable rights issue to raise up to $10.8 million.

Copies of the Prospectus are available on the ASX website (www.asx.com.au) as well as on the Company’s website (www.cbio.com.au).

Only eligible Shareholders registered as holders of shares at the record date of 13 September 2011 with a registered address in Australia or New Zealand may participate in the offer.

The Company considers it unreasonable on this occasion to extend the offer to shareholders with a registered address outside of Australia having regard to the small number of such shareholders and the costs of complying with legal and regulatory requirements in each of those jurisdictions.

Thank you for your continued support of CBio and I trust you understand the Company’s position in this matter.

Yours sincerely

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STEPHEN JONES Executive Chairman