INSMED Inc — Director's Dealing 2025

May 22, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: INSMED Inc (INSM)
CIK: 0001104506
Period of Report: 2025-05-20

Reporting Person: Lewis William (Director, Chair and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-05-20	Common Stock	S	9489	$66.87	Disposed	325798	Direct
2025-05-20	Common Stock	S	4480	$67.96	Disposed	321318	Direct
2025-05-20	Common Stock	S	7088	$68.49	Disposed	314230	Direct
2025-05-20	Common Stock	M	6830	$10.85	Acquired	240754	Indirect
2025-05-20	Common Stock	S	2863	$66.90	Disposed	237891	Indirect
2025-05-20	Common Stock	S	2251	$68.13	Disposed	235640	Indirect
2025-05-20	Common Stock	S	1716	$68.54	Disposed	233924	Indirect

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-05-20	Stock Option (right to buy)	$10.85	M	6830	Disposed	2026-05-19	Common Stock (6830)	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	50500	Indirect

Footnotes

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2: This is the weighted average sales price representing 9,489 shares sold at prices ranging from $66.34 to $67.32 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F3: This is the weighted average sales price representing 4,480 shares sold at prices ranging from $67.38 to $68.37 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F4: This is the weighted average sales price representing 7,088 shares sold at prices ranging from $68.38 to $68.59 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F5: This is the weighted average sales price representing 2,863 shares sold at prices ranging from $66.42 to $67.35 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F6: This is the weighted average sales price representing 2,251 shares sold at prices ranging from $67.49 to $68.47 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F7: This is the weighted average sales price representing 1,716 shares sold at prices ranging from $68.50 to $68.59 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F8: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.