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INSMED Inc Director's Dealing 2025

Sep 4, 2025

30150_dirs_2025-09-04_73c5f847-1e4a-4fb1-b7c3-d29936eb7fb3.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: INSMED Inc (INSM)
CIK: 0001104506
Period of Report: 2025-09-02

Reporting Person: Flammer Martina M.D. (Chief Medical Officer)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2025-09-02 Common Stock M 13680 $34.03 Acquired 96791 Direct
2025-09-02 Common Stock M 17160 $26.46 Acquired 113951 Direct
2025-09-02 Common Stock M 25710 $26.43 Acquired 139661 Direct
2025-09-02 Common Stock M 38846 $17.07 Acquired 178507 Direct
2025-09-02 Common Stock M 13072 $19.74 Acquired 191579 Direct
2025-09-02 Common Stock M 36555 $18.95 Acquired 228134 Direct
2025-09-02 Common Stock M 23835 $29.13 Acquired 251969 Direct
2025-09-02 Common Stock M 17790 $25.83 Acquired 269759 Direct
2025-09-02 Common Stock S 19066 $141.27 Disposed 250693 Direct
2025-09-02 Common Stock S 5877 $142.03 Disposed 244816 Direct
2025-09-02 Common Stock S 35245 $143.16 Disposed 209571 Direct
2025-09-02 Common Stock S 28063 $144.05 Disposed 181508 Direct
2025-09-02 Common Stock S 63782 $145.33 Disposed 117726 Direct
2025-09-02 Common Stock S 34615 $146.05 Disposed 83111 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2025-09-02 Stock Option (right to buy) $34.03 M 13680 Disposed 2031-01-07 Common Stock (13680) Direct
2025-09-02 Stock Option (right to buy) $26.46 M 17160 Disposed 2031-05-12 Common Stock (17160) Direct
2025-09-02 Stock Option (right to buy) $26.43 M 25710 Disposed 2032-01-06 Common Stock (25710) Direct
2025-09-02 Stock Option (right to buy) $17.07 M 38846 Disposed 2032-05-11 Common Stock (38846) Direct
2025-09-02 Stock Option (right to buy) $19.74 M 13072 Disposed 2033-01-05 Common Stock (13072) Direct
2025-09-02 Stock Option (right to buy) $18.95 M 36555 Disposed 2033-05-11 Common Stock (36555) Direct
2025-09-02 Stock Option (right to buy) $29.13 M 23835 Disposed 2034-01-04 Common Stock (23835) Direct
2025-09-02 Stock Option (right to buy) $25.83 M 17790 Disposed 2034-05-13 Common Stock (17790) Direct

Footnotes

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2: This is the weighted average sales price representing 19,066 shares sold at prices ranging from $140.56 to $141.51 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F3: This is the weighted average sales price representing 5,877 shares sold at prices ranging from $141.61 to $142.55 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F4: This is the weighted average sales price representing 35,245 shares sold at prices ranging from $142.70 to $143.69 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F5: This is the weighted average sales price representing 28,063 shares sold at prices ranging from $143.70 to $144.63 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F6: This is the weighted average sales price representing 63,782 shares sold at prices ranging from $144.70 to $145.69 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F7: This is the weighted average sales price representing 34,615 shares sold at prices ranging from $145.70 to $146.51 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F8: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

F9: The options become exercisable based on the following vesting schedule: 25% vest on the first anniversary of the grant date and an additional 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

F10: The options become exercisable based on the following vesting schedule: 25% vest on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the Initial Vesting Date.