IMUGENE LIMITED — Regulatory Filings 2021

Dec 13, 2021

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ASX Announcement

Imugene HER-Vaxx Immunotherapy Patent Allowed in China

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• Chinese patent allowed in major HER-2 positive gastric cancer market

• Patent provides method of composition and method of use protection to 2036

Sydney, Australia, 14 December 2021: Imugene Limited (ASX:IMU) a clinical stage immuno-oncology company today announced it has received a Notice of Allowance from the People's Republic of China Patent Office for Patent Application number 2016800291184 which protects its HER-Vaxx immunotherapy, currently in development for HER-2 positive gastric cancer.

The patent titled “A VACCINE COMPOSITION AND USES THEREOF” protects the method of composition and method of use of Imugene’s HER-Vaxx immunotherapy to 2036.

China has one of the highest incidence rates of gastric cancer worldwide, of which approximately one in five cases are considered HER2 positive. Approximately 75% of all gastric cancer diagnoses are in Asia. Particularly high incidence rates in East Asia make China a very large market for gastric cancer medications.[1]

Imugene’s M.D. & CEO, Ms Leslie Chong said: “Attaining the key Chinese patent is an important milestone. This adds to Imugene’s portfolio of B-cell immunotherapies and this will protect them in one of the world’s largest HER-2 positive gastric cancer market until 2036.”

Imugene’s HER-Vaxx is a B-cell activating immunotherapy designed to treat tumours that over-express the HER-2/neu receptor, such as gastric, breast, ovarian, lung and pancreatic cancers. The immunotherapy is constructed from several B cell epitopes derived from the extracellular domain of HER-2/neu. It has been shown in pre-clinical studies, in Phase I and now Phase 2 studies to stimulate a potent polyclonal antibody response to HER-2/neu, a well-known and validated cancer target.

For more information please contact:

Leslie Chong

Managing Director and Chief Executive Officer info@imugene.com

Investor Enquires

investor@imugene.com

IMUGENE LIMITED ACN 009 179 551 WWW.IMUGENE.COM info@imugene.com

Media Enquires Matt Wright matt@nwrcommunications.com.au

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Connect with us on LinkedIn @Imugene Limited

Reference:

1 GLOBOCAN 2018 Graph production: IARC. World Health Organization. August 2020.

About Imugene (ASX:IMU)

Imugene is a clinical stage immuno-oncology company developing a range of new and novel immunotherapies that seek to activate the immune system of cancer patients to treat and eradicate tumours. Our unique platform technologies seek to harness the body’s immune system against tumours, potentially achieving a similar or greater effect than synthetically manufactured monoclonal antibody and other immunotherapies. Our product pipeline includes multiple immunotherapy B-cell vaccine candidates and an oncolytic virotherapy (CF33) aimed at treating a variety of cancers in combination with standard of care drugs and emerging immunotherapies such as CAR T’s for solid tumours. We are supported by a leading team of international cancer experts with extensive experience in developing new cancer therapies with many approved for sale and marketing for global markets.

Our vision is to help transform and improve the treatment of cancer and the lives of the millions of patients who need effective treatments. This vision is backed by a growing body of clinical evidence and peer-reviewed research. Imugene is well funded and resourced, to deliver on its commercial and clinical milestones. Together with leading specialists and medical professionals, we believe Imugene’s immunooncology therapies will become foundation treatments for cancer. Our goal is to ensure that Imugene and its shareholders are at the forefront of this rapidly growing global market.

Release authorised by the Managing Director and Chief Executive Officer Imugene Limited, Level 3, 62 Lygon Street, Carlton, VIC, 3053, Australia

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IMUGENE LIMITED ACN 009 179 551