IMUGENE LIMITED — Director's Dealing 2025

Jul 22, 2025

Appendix 3Y Change of Director's Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX becomes ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

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----- Start of picture text ----- Name of entity Imugene LimitedABN 99 009 179 551----- End of picture text -----

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

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----- Start of picture text ----- Name of director Leslie ChongDate of last notice 21 February 2025----- End of picture text -----

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

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----- Start of picture text ----- Direct or indirect interest DirectNature of indirect interest Ms Chong is a trustee for the Chong Super Fund TC(including registered holder) Pty Ltd.Date of change 21 July 2025No. of securities held prior to change (1) 2,448,377 - Direct ORDINARY FULLY PAIDSHARES(2) 220,718 - Indirect ORDINARY FULLY PAIDSHARES(3) 597,059 - Employee Share Option Plan - Options(4) 52,047,544 - Employee Share Option Plan -Performance Rights(5) 85,785 - OPTIONS @ $4.012 EXP 31/08/2026Class (1) Direct ORDINARY FULLY PAID SHARES(2) Indirect ORDINARY FULLY PAID SHARES(3) Employee Share Option Plan - Options(4) Employee Share Option Plan - PerformanceRights(5) OPTIONS @ $4.012 EXP 31/08/2026----- End of picture text -----

• See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director's Interest Notice

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----- Start of picture text ----- Number acquired (1) 170,405 - Direct ORDINARY FULLY PAIDSHARES.Number disposed (1) 170,405 - Employee Share Option Plan -Performance RightsValue/Consideration (1) NIL Consideration - Direct ORDINARY FULLYPAID SHARESNo. of securities held after change (1) 2,618,782 - Direct ORDINARY FULLY PAIDSHARES(2) 220,718 - Indirect ORDINARY FULLY PAIDSHARES(3) 597,059 - Employee Share Option Plan - Options(4) 51,877,139 - Employee Share Option Plan -Performance Rights(5) 85,785 - OPTIONS @ $4.012 EXP 31/08/2026Nature of change Employee Plan - Awards Exercised to FPOPlease note that the figures stated in this formreflect the post-share consolidation position----- End of picture text -----

Part 2 - Change of director's relevant interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

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----- Start of picture text ----- Detail of contract N/ANature of interest N/AName of registered holder N/A(if issued securities)Date of change N/ANo. and class of securities N/Ato which interest relatedprior to changeInterest acquired N/AInterest disposed N/AValue/Consideration N/AInterest after change N/A----- End of picture text -----

Part 3 -[+] Closed period

• See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 2

Appendix 3Y Change of Director's Interest Notice

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----- Start of picture text ----- Were the interests in the securities or Nocontracts detailed above traded during a+closed period where prior written clearancewas required?If so, was prior written clearance provided to N/Aallow the trade to proceed during this period?If prior written clearance was provided, on N/Awhat date was this provided?----- End of picture text -----

• See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 3

Appendix 3Y Change of Director's Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX becomes ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

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----- Start of picture text ----- Name of entity Imugene LimitedABN 99 009 179 551----- End of picture text -----

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

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----- Start of picture text ----- Name of director Paul HopperDate of last notice 21 February 2025----- End of picture text -----

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

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----- Start of picture text ----- Direct or indirect interest IndirectNature of indirect interest Director's related parties(including registered holder)Date of change 21 July 2025No. of securities held prior to change (1) 125,757 - Direct Shares ORDINARY FULLYPAID SHARES(2) 11,932,066 - Indirect Shares ORDINARY FULLYPAID SHARES(3) 85,785 - OPTIONS @ $4.012 EXP 31/08/2026(4) 85,295 - Employee Share Option Plan - Options(5) 164,954 - Employee Share Option Plan -Performance RightsClass (1) Direct Shares ORDINARY FULLY PAIDSHARES(2) Indirect Shares ORDINARY FULLY PAIDSHARES(3) OPTIONS @ $4.012 EXP 31/08/2026(4) Employee Share Option Plan - Options(5) Employee Share Option Plan - PerformanceRightsNumber acquired (2) 28,688 - Indirect Shares ORDINARY FULLYPAID SHARESNumber disposed (5) 28,688 - Employee Share Option Plan -Performance Rights----- End of picture text -----

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director's Interest Notice

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----- Start of picture text ----- Value/Consideration (2) NIL Consideration - Indirect Shares ORDINARYFULLY PAID SHARESNo. of securities held after change (1) 125,757 - Direct Shares ORDINARY FULLYPAID SHARES(2) 11,960,754 - Indirect Shares ORDINARY FULLYPAID SHARES(3) 85,785 - OPTIONS @ $4.012 EXP 31/08/2026(4) 85,295 - Employee Share Option Plan - Options(5) 136,266 - Employee Share Option Plan -Performance RightsNature of change Employee Plan - Awards Exercised to FPOPlease note that the figures stated in this formreflect the post-share consolidation position----- End of picture text -----

Part 2 - Change of director's relevant interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

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----- Start of picture text ----- Detail of contract N/ANature of interest N/AName of registered holder N/A(if issued securities)Date of change N/ANo. and class of securities N/Ato which interest relatedprior to changeInterest acquired N/AInterest disposed N/AValue/Consideration N/AInterest after change N/A----- End of picture text -----

Part 3 -[+] Closed period

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----- Start of picture text ----- Were the interests in the securities or Nocontracts detailed above traded during a+closed period where prior written clearancewas required?If so, was prior written clearance provided to N/Aallow the trade to proceed during this period?If prior written clearance was provided, on N/Awhat date was this provided?----- End of picture text -----

• See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 2