IMUGENE LIMITED — Capital/Financing Update 2019

Nov 24, 2019

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ASX Announcement

CF33 Oncolytic Virus GMP Manufacturing Update

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SYDNEY Australia 25 November 2019: Imugene Limited (ASX: IMU) is pleased to provide a GMP manufacturing update for its CF33 oncolytic virus technology, which is due to enter clinical trials in 2020.

The CF33 oncolytic virus (OV) was developed in the lab of Professor Yuman Fong, an internationally recognised surgeon and scientist at City of Hope, a world-renowned independent research and treatment centre for cancer, diabetes and other life-threatening diseases based in California.

As previously announced, CF33 has been developed in two different constructs: one version of the OV is “armed” with an immune checkpoint inhibitor inserted in the virus, which is known as CheckVacc; and the other an unarmed construct, known as Vaxinia. It is planned by Imugene that two separate Phase 1 clinical trials will be conducted in 2020 to test a CheckVacc construct and a Vaxinia construct of the OV.

Both constructs have completed clinical grade GMP batches at the City of Hope Center for Biomedicine and Genetics (CBG).

The CBG is a California-licensed, 20,000 square foot, multi-product biologics manufacturing facility within City of Hope. With twelve ISO 7 production rooms in three product type “zones”, a dedicated aseptic fill suite and a staff with extensive biopharmaceutical experience, the CBG is capable of producing virtually any type of biologic at scales suitable for Phase I through Phase II clinical trials.

Imugene’s M.D. & CEO, Ms Leslie Chong said, “This is a significant milestone met in our preparation for commencing our planned CF33 oncolytic virus Phase 1 clinical trials in 2020”.

For further information please contact:

Leslie Chong Managing Director and Chief Executive Officer T: +61 458 040 433

E: Leslie.Chong@Imugene.com

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IMUGENE LIMITED ACN 009 179 551 WWW.IMUGENE.COM info@imugene.com

About Imugene (ASX:IMU)

Imugene is a clinical stage immuno-oncology company developing a range of new and novel immunotherapies that seek to activate the immune system of cancer patients to treat and eradicate tumors. Our unique platform technologies seek to harness the body’s immune system against tumours, potentially achieving a similar or greater effect than synthetically manufactured monoclonal antibody and other immunotherapies. Our product pipeline includes multiple immunotherapy B-cell vaccine candidates and an oncolytic virotherapy (CF33), aimed at treating a variety of cancers in combination with standard of care drugs and emerging immunotherapies. We are supported by a leading team of international cancer experts with extensive experience in developing new cancer therapies with many approved for sale and marketing for global markets.

Our vision is to help transform and improve the treatment of cancer and the lives of the millions of patients who need effective treatments. This vision is backed by a growing body of clinical evidence and peer-reviewed research. Imugene is well funded and resourced, to deliver on its commercial and clinical milestones. Together with leading specialists and medical professionals, we believe Imugene’s immuno-oncology therapies will become foundation treatments for cancer. Our goal is to ensure that Imugene and its shareholders are at the forefront of this rapidly growing global market.

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IMUGENE LIMITED ACN 009 179 551