IMPEDIMED LIMITED — Director's Dealing 2010

May 20, 2010

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity	IMPEDIMED LIMITED
ABN	65 089 705 144

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Dr Cherrell Hirst
Date of last notice	6 July 2009

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct & Indirect
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest.	Direct - Dr Cherrell Hirst Indirect – Bond St Custodians (Super) Indirect - Macquarie Pension Manager
Date of change	17 May 2010
No. of securities held prior to change	Dr Cherrell Hirst (Direct) • 154,745 Ordinary Shares Bond Street Custodians (Indirect, as trustee for Cherrell Hirst Super Fund) • 38,334 Ordinary Shares • 17,250 Options to subscribe for Ordinary Shares at an exercise price of $0.7079 per Share Macquarie Pension Manager (Indirect - A/c Cherrell Hirst) • 10,500 Ordinary Shares
Class	Ordinary Shares
Number acquired	Dr Cherrell Hirst 19,344 Bond St Custodians (Super) 4,792 Macquarie Pension Mgr 1,313

• See chapter 19 for defined terms.

Appendix 3Y Page 1

11/3/2002

Appendix 3Y Change of Director’s Interest Notice

Number disposed	-
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation	Dr Cherrell Hirst $12,574 Bond Street Custodians (Super) $3,115 Macquarie Pension Mgr $853 (65 cents per shares)
No. of securities held after change	Dr Cherrell Hirst (Direct) • 174,089 Ordinary Shares Bond Street Custodians (Indirect, as trustee for Cherrell Hirst Super Fund) • 43,126 Ordinary Shares • 17,250 Options to subscribe for ordinary shares at an exercise price of $0.7079 per share Macquarie Pension Manager (Indirect - A/c Cherrell Hirst) • 11,813 Ordinary Shares
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	Subscription under Entitlement Offer dated 19 April 2010

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract Nature of interest Name of registered holder (if issued securities) Date of change No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed Interest acquired Interest disposed Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation Interest after change

• See chapter 19 for defined terms.

Appendix 3Y Page 2

11/3/2002