ILLUMINA, INC. — Proxy Solicitation & Information Statement 2022

Apr 14, 2022

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

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☐ Definitive Proxy Statement

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Illumina, Inc.

(Name of Registrant as Specified In Its Charter)

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Your Vote Counts! ILLUMINA, INC. 2022 Annual Meeting Vote by May 25, 2022 11:59 PM ET illumina ILLUMINA, INC. 5200 ILLUMINA WAY SAN DIEGO, CA 92122 ATTN: SALLI SCHWARTZ You invested in ILLUMINA, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on May 26, 2022. Get informed before you vote View the Notice & Proxy Statement, Form 10-K online OR you can received a free paper or email copy of the material(s) by requesting prior to May 12, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmatierial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. PV For complete information and to vote, visit www.ProxyVote.com Control # Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* May 26, 2022 9:00 AM PDT Meeting live via the Internet - please visit www.virtualshareholdermeeting.com/ILMN2022 *Please check the meeting material for any special requirements for meeting attendance.

Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an Overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Voting Items Board Recommends 1. Election of Directors Nominees: For 1A Frances Arnold, Ph.D. For 1B Francis A. deSouza For 1C Caroline D. Dorsa For 1D Robert S. Epstein, M.D. For 1E Scott Gottlieb, M.D. For 1F Gray S. Guthart, Ph.D. For 1G Philip W. Schiller For 1H Susan E. Siegel For 1I John W. Thompson For 2 To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending January 1, 2023. For 3 To approve, on an advisory basis, the compensation of the named executed officers as disclosed in the Proxy Statement. For 4 To approve, on an advisory basis, a stockholder proposal regarding the right of stockholders to call special meetings. Against 5 To approve an amendment to our Amended and Restated Certificate of Incorporation to permist stockholders to call special meetings. For NOTE: Such other business as may properly come before the meeting or any adjournment thereof. You may attend the Meeting via the Internet and vote during the meeting. Have the information that is printed in the box marked with the arrow on your proxy card or Notice of Internet Availability of Proxy Materials available and follow the instructions. Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”.