ILLUMINA, INC. — Director's Dealing 2011

May 12, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ILLUMINA INC (ILMN)
CIK: 0001110803
Period of Report: 2011-05-10

Reporting Person: HENRY CHRISTIAN O (Sr VP & CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-10	Common Stock	M	3329	$32.485	Acquired	32784	Direct
2011-05-10	Common Stock	S	3329	$73.6567	Disposed	29455	Direct
2011-05-10	Common Stock	M	900	$32.485	Acquired	30355	Direct
2011-05-10	Common Stock	S	900	$74.6378	Disposed	29455	Direct
2011-05-10	Common Stock	M	771	$32.485	Acquired	30226	Direct
2011-05-10	Common Stock	S	771	$75.5136	Disposed	29455	Direct
2011-05-10	Common Stock	M	5006	$20.04	Acquired	34461	Direct
2011-05-10	Common Stock	S	5006	$73.6673	Disposed	29455	Direct
2011-05-10	Common Stock	M	1400	$20.04	Acquired	30855	Direct
2011-05-10	Common Stock	S	1400	$74.6707	Disposed	29455	Direct
2011-05-10	Common Stock	M	1094	$20.04	Acquired	30549	Direct
2011-05-10	Common Stock	S	1094	$75.5383	Disposed	29455	Direct
2011-05-10	Common Stock	M	3376	$10.485	Acquired	32831	Direct
2011-05-10	Common Stock	S	3376	$73.6761	Disposed	29455	Direct
2011-05-10	Common Stock	M	900	$10.485	Acquired	30355	Direct
2011-05-10	Common Stock	S	900	$74.6889	Disposed	29455	Direct
2011-05-10	Common Stock	M	724	$10.485	Acquired	30179	Direct
2011-05-10	Common Stock	S	724	$75.525	Disposed	29455	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-10	Non-Qualified Stock Option (right to buy)	$10.485	M	5000	Disposed	2016-01-30	Common Stock (5000)	Direct
2011-05-10	Non-Qualified Stock Option (right to buy)	$20.04	M	7500	Disposed	2017-01-25	Common Stock (7500)	Direct
2011-05-10	Non-Qualified Stock Option (right to buy)	$32.485	M	5000	Disposed	2018-01-29	Common Stock (5000)	Direct

Footnotes

F1: The sale was made pursuant to a 10b5-1 plan.

F2: Weighted average sale price representing 3,329 shares sold ranging from $73.22 to $74.17 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F3: Weighted average sale price representing 900 shares sold ranging from $74.35 to $75.06 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F4: Weighted average sale price representing 771 shares sold ranging from $75.35 to $76.03 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F5: Weighted average sale price representing 5,006 shares sold ranging from $73.22 to $74.19 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F6: Weighted average sale price representing 1,400 shares sold ranging from $74.33 to $75.10 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F7: Weighted average sale price representing 1,094 shares sold ranging from $75.41 to $76.00 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F8: Weighted average sale price representing 3,376 shares sold ranging from $73.24 to $74.21 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F9: Weighted average sale price representing 900 shares sold ranging from $74.40 to $75.08 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F10: Weighted average sale price representing 724 shares sold ranging from $75.41 to $75.77 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.