GlaxoSmithKline PLC — Major Shareholding Notification 2012

Feb 13, 2012

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

NuPathe Inc.

(Name of issuer)

Common Stock

(Title of class of securities)

67059M100

(CUSIP number)

June 8, 2011

(Date of event which requires filing of this statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)

¨ Rule 13d-1(c)

x Rule 13d-1(d)

• The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who respond to the collection of information contained in this form are not

required to respond unless the form displays a currently valid OMB control number.

SCHEDULE 13G

CUSIP No. 67059M100 Page 2 of 5 Pages

(1)	Names of reporting persons GlaxoSmithKline plc
(2)	Check the
appropriate box if a member of a group (see instructions) (a) ¨ (b) ¨
(3)	SEC use
only
(4)	Citizenship or
place of organization England and
Wales
Number of shares beneficially owned by each reporting person with:	(5)	Sole voting power 1,166,846
	(6)	Shared voting power 0
	(7)	Sole dispositive power 1,166,846
	(8)	Shared dispositive
power 0
(9)	Aggregate amount beneficially
owned by each reporting person 1,166,846
(10)	Check if the aggregate amount in
Row (9) excludes certain shares (see instructions) ¨
(11)	Percent of class represented by
amount in Row (9) 7.9%
(12)	Type of reporting person (see
instructions) CO

SCHEDULE 13G

CUSIP No. 67059M100 Page 3 of 5 Pages

ITEM 1.

(a) Name of Issuer:

NuPathe Inc.

(b) Address of Issuer’s Principal Executive Offices:

227 Washington Street

Suite 200

Conshohocken, PA 19428

ITEM 2.

(a) Name of Person Filing:

GlaxoSmithKline plc

(b) Address of Principal Business Office, or if None, Residence:

980 Great West Road

Brentford

Middlesex

TW8 9GS ENGLAND

(c) Citizenship:

England and Wales

(d) Title of Class of Securities:

Common Stock, par value $0.001 per share

(e) CUSIP Number:

67059M100

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13d-1(b) OR 240.13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

Not Applicable

ITEM 4. OWNERSHIP.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

The information in items 1 and 5 through 11 on the cover pages (page 2) on Schedule 13G is hereby incorporated by reference.

S.R. One, Limited, a wholly-owned subsidiary of the Reporting Person, is the record holder of 1,151,211 shares of Common stock and an additional 15,635 shares of Common stock which may be acquired by S.R. One, Limited upon the exercise of warrants. As of June 8, 2011, 7,486 stock options lapsed following Michael Diem’s resignation as a Director of the Issuer.

SCHEDULE 13G

CUSIP No. 67059M100 Page 4 of 5 Pages

ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ¨ .

ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

	September 30,	September 30,	September 30,
S.R. One, Limited*	Common Stock	1,151,211
	Warrants	15,635
		1,166,846	7.9 %

As of June 8, 2011, 7,486 stock options lapsed following Michael Diem’s resignation as a Director of the Issuer.

ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

N.A.

ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

N.A.

ITEM 9. NOTICE OF DISSOLUTION OF GROUP.

N.A.

SCHEDULE 13G

CUSIP No. 67059M100 Page 5 of 5 Pages

ITEM 10. CERTIFICATIONS.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

February 10, 2012

(Date)

/s/ Victoria A. Whyte

(Signature)

Victoria A. Whyte,

Company Secretary

(Name/Title)

The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative’s authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.