GeneDx Holdings Corp. — Director's Dealing 2021

Nov 3, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Sema4 Holdings Corp. (SMFR)
CIK: 0001818331
Period of Report: 2021-10-25

Reporting Person: Saad Kareem (Chief Business Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-10-25	Class A Common Stock	M	54042	—	Acquired	54042	Direct
2021-10-25	Class A Common Stock	S	16608	$7.54	Disposed	37434	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-10-25	Restricted Stock Unit	$	M	54042	Disposed		Class A Common Stock (54042)	Direct

Footnotes

F1: Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration.

F2: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F3: 3/16th of the total shares vested on October 25, 2021, 1/16th of the total shares vest on January 19, 2022, and thereafter vests as to 1/16th of the total shares underlying the award in quarterly installments until fully vested on January 19, 2025, subject to the Reporting Person's continued service to the Issuer on each vesting date.