Galapagos NV

Pre-Annual General Meeting Information • Mar 27, 2025

GALAPAGOS NV

Limited tiability company Generaal De Wittelaan Ll1 43, 2800 Mechelen, Belgium Com pa ny N u m ber: 0466.460.429 RLE Antwerp - division Mechelen

^fnvitation to the Annual Shareholdersr Meeting to be held on April29r2025

The Boa rd of Directors of Gala pagos NV (hereinafter the "Company", o r "Galapagos") has the honor to ínvite the shareholders, holders of subscription rights, directors, and statutory auditor of the Company to the a n n ual sha reholders' meeting (hereinafter the "Annual Shareholders' Meeting"). The AnnuaI Sha reholders' Meeting witt be held on Tuesday April 29, 2025, al2:00 p.m. (Betgian time) atthe registered office of the Company (Generaal De Wittelaan 111A3, 2800 Mechelen, Belgium).

Agenda and proposed resolutions

The agenda and the proposed resolutions ofthe AnnuaI Shareholders' Meeting ofthe Company which, as the case may be, can be amended at the meeting on behalf of the Board of Directors, are as follows:

• 1. Acknowledgement and discussion of (a) the annuaI report of the Board of Directors in relation to the non-consolidated and consolidated annuaI accounts of the Company for the financial year ended on December 37,2024, and (b) the report of the statutory auditor in relation to the non-consolídated annuaI accounts ofthe Company forthefinancialyear ended on December31,2024.
• 1. Acknowledgement and approvaI of the non-consolidated annuaI accounts of the Company for the financial year ended on December 3L,2024, and approval of the attocation of the annual result as proposed by the Board of Directors.

Prooosed resolution: The shareholders' meeting resolves to approve the non-consotidated annual accounts of the Company for the financialyear ended on Decemb er 3I,2024, and the allocation of the annual result as proposed bythe Board ofDirectors.

• Acknowledgement and discussion of the report of the statutory auditor relating to the consotídated annualaccountsoftheCompanyforthefinancialyearendedon December31,2024. 3.
• Acknowledgement and discussion of the consotidated annual accounts of the Company for the financiaI year ended on December 31,2024. 4.
• Acknowledgement and approval of the remuneration report. 5.

Proposed resolution: The shareholders' meeting resolves to approve the remuneration report included in the annual report of the Board of Directors for the financial year ended on December 31, 2024.

1. Release from liabitity to be granted to the (current and former) members of the Board of Directors, and the statutory auditorforthe performance of their respective mandates during the financialyear ended on December3\,2024.

Proposed resolution: The shareholders' meeting resolves, by a separate vote, to release each (current and former) member of the Board of Directors, and the statutory auditor from any liability arising from the performance of their respective mandates during the financialyear ended on December 37,2024.

1. Appointment of Mr. Oteg Nodelman as non-executive director

Taking into account the recommendation and advice of the Nomination Committee, the Board of Directors recommends that the appointment of Mr. Oleg Nodelman as non-executive director of the Company be confirmed and continued for an additionat term of four years. Notably, on October 6, 2024,and with effect as per October7,2024,the Board of Directors appointed Mr. Oleg Nodelman as non-executive director of the Company by co-optation fottowing the resignation of Mr. DanieI Baker on October 6,2024, as independent non-executive director, who was appointed for a term up to and including the closing of the annual shareholders' meeting to be held in 2Q26 which witl have decided upon the financiaI statements for the financial year ended on December 31, 2025.

Proposed resolution: Upon proposal of the Board of Directors, and in accordance with the recommendation and advice of the Nomination Committee, the sharehotders' meeting resolves (a) to confirm the appointment by co-optation on October 6,2024, and with effect as per October 7,2024, following the resignation of Mr. Daniel Baker on October 6,2024, and to appoint Mr. Oleg Nodetman as a non-executive mem ber of the Board of Directors of the Company, for an additionat period of four years, up to and including the closing of the annualshareholders' meetíngto be hetd in 2029 which wi[[ have decided upon the financiaI statements for the financìal year ended on December 3I,2028. The sharehotders' meeting also resolves that the mandate of Mr. Oleg Nodelman will not be remunerated.

1. Confirmation and appointment of the statutory auditor with respect to the "assurance" of the CSRD sustainability reporting.

Prooosed resolution: ln accordance with the recommendation of the Audit Committee and upon proposal of the Board of Directors, and taking into account that the Corporate Sustainability Reporting Directive 2022124641EU ("CSRD") in the meantime has been transposed into Belgian law, the shareholders' meeting resolves (a) as far as needed and required, to confirm and ratify the decision by the annual general shareholders' meeting, which prior to the aforementioned transposition of the CSRD took place on April 30,2024, to charge the Company's statutory auditor, being BDO Bedrijfsrevisoren BV, with its registered office at Da Vincilaan 9/E.6, 1930 Zaventem, and registered with the Crossroads Enterprise Database (RPR Brussels, Dutch-spea king d ivision) u nder the nu mber 0431.088.289, permanently represented by Etten Lombaerts, for a period of one year, with the assu rance of the sustainability reporting of the Company, as referred to in the CSRD, for the financìaI year ending on December 3L,2024 in accordance with applicable law, (b) taking into account the aforementioned transposition of the CSRD that in the meantime has taken place, to extend the aforementioned mandate of BDO Bedrijfsrevisoren BV forthe assurance of the sustainabitity reporting of the Company, as referred to in articles 3:617 - 3:6/8 and articles 3:321I - 3:3216 of the Belgian Companies and Associations Code for a period of one year, to include also the assurance of the sustainability reporting of the Company for the financiaI year ending on December 3I,2025, so that (taking into account the provisions of article 3:6J-, 58 of the Belgian Companies and Associations Code) the first term of the statutory mandate of the statutory auditor for the assurance of the susta¡nability reporting of the Company in accordance with applicable law is aligned with the current mandate of the statutory auditor to audit the Company's annual financiaI statement (which sha[[ expire immediately after the annual shareholders' meeting to be held in2026), and (c) to determine the remuneration of BDO Bedrijfsrevisoren BV for the assurance of the Company's sustainability reporting for the financiaI year ending on December 3I,2025 at EUR 80,000.00 (if any, VAT exclusive). The appointment of the statutory auditor with respect to the aforementioned assurance wi[[ expire immediately after the annuaI shareholders' meeting to be held in2026.

No dttendance quorumi There is no attendance quorum requirement for the deliberation and voting on the agenda items referred to in the aforementioned agenda of the AnnuaI Sharehotders' Meeting.

Voting ønd majority: Subject to applicable [ega[ provisions, each share sha[[ have one vote. ln accordance

Free translat¡on from Dutch For ¡nformat¡on purposes only

Registration and admission formalities

To be admitted to the Annual Shareholders' Meeting, the holders of securities issued by the Company must comply with (a) article 7:134 of the Belgian Companies and Associations Code, and (b) article 23 of the Company's articles of association, as well as complete the formalities and make the notifications further described below.

Only shareholders are entitled to vote at the Annual Shareholders' Meeting. The holders of subscription rights issued by the Company can, in accordance with article 7:135 of the Belgian Companies and Associations Code, only attend the AnnuaI Shareholders' Meeting with an advisory vote. Article 23 of the Company's artictes of association determines the formalities that these security holders must complete to be admitted to the AnnuaI Shareholders' Meeting.

ln order to be able to participate to the Annual Shareholders' Meeting, a holder of shares or subscription rights issued by the Company must satisfy two conditions: (i) be registered as holder of such shares or subscription rights on the Record Date (as defined below), and (ii) notify the Company thereof, as described below:

• 1. Registration: Firstly, the right for a holder of shares or subscription rights issued by the Company to participate to and, as applicable, to vote at the AnnuaI Shareholders' Meeting is only granted on the basis of the registration of the securities concerned on April 15, 2025 at midnight (2a:00) (Betgian time) (hereinafter the "Record pate"), via registration, ín the appticable register book for the securìties concerned (for registered securities) or in the accounts of a certified account holder or the relevant central securities depository for the securities concerned (for dematerialised secu rities), and this irrespective of the number of shares or subscription rights that they hold on the date ofthe Annual Shareholders' Meeting.
• 1. Notification: Second ly, in order to be ad mitted to the An n u a I Shareholders' Meeting, the holders of shares or subscription rights issued by the Company must notify the Company in writing that they have the intention to participate to the meeting and must do so prior to or at the latest on April 23, 2025. The holders of securities that wìsh to make such notification can make use of the registration notice form that can be obtained at the Company's registered office and on the Company's website (www.gtpg.com/shareholders-meetings). The notice must reach the Company by e-mail at shareholders@glpg.com or by mail at its registered office (Generaal De Wittelaan 111 A3, 2800 Mechelen, Belgium, Attention: Ms. Annelies Denecker) at the [atest on the sixth calendar day prior to the AnnuaI Shareholders' Meeting, i.e., on or before April 23, 2025 at the latest. For the holders of dematerialised shares, the notification should include a certificate confirming the number of shares that have been registered in their name on the Record Date. The certificate can be obtained by the holders of the dematerialised shares with the certified account holder, the relevant centraI securities depository, or the retevant financiaI intermediary for the shares concerned.

Only persons who are a holder of shares or subscription rights of the Company on the Record Date and have indicated their intention to participate in the AnnualShareholders' Meeting as set out above, wilt be entitled to participate in, and, in the case of shares, vote at, the AnnuaI Shareholders' Meeting.

Proxy

ln accordance with article 24 of the Company's articles of association, shareholders having complied with the registration and admission formalities set out above, may be represented at the Annual Sharehotders' Meeting by the General Counsel of the Company, with power of substitution, in her capacity as proxy holder,

Free translat¡on from Dutch

Shareholders who so wish to be represented by proxy, should use the proxy form (with voting instructions) made avaí[able on the Company'swebsite (www.glpg.com/shareholders-meetings). The signed proxy form must be submitted to Galapagos by e-mai[ (shareholders@glpg.com) or by mait (Galapagos NV, attn.: Ms. Anneties Denecker, GeneraaI De Wittelaan 111 43, 2800 Mechelen, Belgium), and must reach Galapagos by no later than April 23, 2025.

Vot¡ng by tetter

Shareholders' Meeting.

ln accordance with article 7:146 of Belgian Companies and Associations Code, and article 24 of lhe Company's articles of association, sharehotders having complied with the registration and admission formalities set out above, are atlowed to vote by letter - prior to the Annuat Shareholders' Meeting - by means of a form made available on the Company's website (www.glpg.com/shareholders-meetings).

The signed form must be submitted to Galapagos by e-mait (shareholders@glpg.com) or by mait (Gatapagos NV, attn.: Ms. Annelies Denecker, GeneraaI De Wittelaan 111 A3,2800 Mechelen, Belgium), and must reach Galapagos by no later than April 23,2025.

Right to ask questions

ln accordance with article 7:139 of the Belgian Companies and Associations Code, and article 28 of the articles of association of the Company, shareholders and holders of subscription rights issued by the Company, are entitled, whether during the AnnuaI Shareholders' Meeting or in wríting before the meeting, to ask questions to (a) the members of the Board of Directors with respectto its report, orthe agenda items, and (b) the statutory auditorwith respect to its report.

Questions asked in writing, wit[ onty be answered if the relevant shareholder, or hotder of subscription rights, has futfilled the registration and admission formalities set out above, and if the written question has been received by the Company at the latest on April 23r2025. Any written questions must be submitted to Galapagos by e-mail (shareholders@glpg.com) or by mail (Galapagos NV, attn.: Ms. Annelies Denecker, GeneraaI De Wittelaan 11143, 2800 Mechelen, Betgium).

Right to add agenda items

ln accordance with article 7:130 of the Belgian Companies and Associations Code, and article 22 of the articles of association of the Company, one or more shareholders who alone or together possess at least 3% of the share capital of the Company, and provided that the applicable legaI restrictions have been complied with, may request for additional items to be added to the agenda of the AnnuaI Shareholders' Meeting, and submit proposed resolutions in relation to existing agenda items or new items to be added to the agenda. Such request, along with proof of ownership of the required participation, and, as the case may be, the text of the items to be dealt with and related proposed resolutions, must be submitted to Galapagos by e-mail (shareholders@glpg.com) or by mait (Gatapagos NV, attn.: Ms. Annelies Denecker, Generaal De Wittelaan 111 43,2800 Mechelen, Belgium), and must reach Galapagos by no laterthan April7 r2O25. As the case may be, the Company witt pubtish a modified agenda for the Annual Shareholders' Meeting at the latest on April 14, 2025.

Availability of documents

The documentation relating to the AnnuaI Shareholders' Meeting, or that must be made available pursuant to the applicable laws, as we[[ as the totaI number of shares and voting rights at the date hereof, are made availabte on the Company's website (www.glpg.com/shareholders-meetings). Any hard copies of this

documentation can be obtained at no cost by e-mail (shareholders@glpg.com) or by mail (Galapagos NV, attn.: Ms. Annelies Denecker, GeneraaI De Wittelaan 111A3, 2800 Mechelen, Belgium).

Ptease address any requests for more information to the LegaI department of Galapagos (+¡z rS 342 900). Correspondence ca n be sent by e-ma i[ (shareholders@glpg.com) or by m a il (Gata pagos NV, attn.: Ms. Annelies Denecker, GeneraaI De Wittelaan L1]- A3, 2800 Mechelen, Belgium).

Misce[[aneous

To facilitate an expedient registration, the participants are requested to be present at least ]-5 minutes prior to the start ofthe Annual Shareholders' Meeting.

The convening notice for the AnnuaI Shareholders' Meeting is d rafted in Dutch and English, it being however understood that (i) the Engtish version of the convening notice is only a free translation for information purposes, and (ii) in case ofan inconsistency between the Dutch and English version ofthe convening notice, the Dutch version will at al[ times prevail.

The natural persons who íntend to attend the Annual Shareholders' Meeting in their capacity as holder of securities, proxy holders, or representatives of a legaI entíty, must provide evidence of their identity in order to be granted access to the meeting. ln addition, the representatives of legal entities must hand over all documents establishing their capacity as corporate representative or attorney-in-fact. These documents wi[[ be verified immedìately before the start of the AnnuaI Shareholders' Meeting.

Data protect¡on

The Company is responsible for the processing of personal data it receives from, or collects about, holders of securities issued by the Company and proxy holders in the context of shareholders' meetings. The processing ofsuch data witl be carried out for the purposes ofthe organization and conduct ofthe relevant shareholders' meeting, including (without timitation) the convening notices, registrations, attendance and voting, as wetl as for maintaining lists or registers of security hotders, and the analysis of the investor and security holder base of the Company. These data include, amongst others, identification data, the number and nature of securities of any holder of securities issued by the Company, proxies and voting instructions. These data may also be transferred to third parties for the purposes of assistance or services to the Company in connection with the foregoing. The processing of the above data will be carried out, mutotis mutandis,in accordance with the Company's Privacy Statement, available on the Company's website (www.glpg.com/privacy-notice). Ihe Company draws the attention of the hotders of securities issued by the Company and proxy holders to the description of the ríghts they may have as data subjects, such as, among others, the right to access, the right to rectify and the right to object to processing, which are further outtined in the section 'Your rights as a data subject'of the aforementioned Privacy Statement. Alt this does not affect the rules that appty in connection with the registration and participation to the shareholders' meeting. To exercise rights as a data subject, as we[[ as for a[[ other information regarding the processing of personal data by or on behalf of the Company, the Company can be contacted by e-mait at dpo@gtpg.com.

On beholf of the Board of Directors

Kennisgeving van deelname

(enkel te gebruiken door houders van aandelen op naam of inschrijvingsrechten, die geregistreerd werden op 15 april 202s)

Notification of paʡcipation

(to be used by holders of registered shares or subscription rights only, registered on 15 April 2025)

De ondergetekende The undersigned

en adres / Nante and

heeft kennis genomen van de agenda van de Gewone Algemene Vergadering van Galapagos NV (een naamloze vennootschap naar Belgisch recht met zetel te Generaal De Wittelaan L11 A3, 2800 Mechelen, België, ingeschreven in het Rechtspersonenregister (Antwerpen, afdeling Mechelen) onder het nummer 0466.460.429) (de "Vennootschap'),

die zal plaatsvinden op dinsdag 29 april 2025 om 14.00 uur(Belgische tijd) op de zetel van de Vennootschap,

en brengt de Vennootschap hierbij op de hoogte van zijnlhaar voornemen om deel te nemen aan de Gewone Algemene Vergader¡ng die zal plaatsvinden op dinsdag 29 april 2025,

met de volgende effecten:

has taken note of the agenda of the Annual Shareholders' Meeting of Galapagos NV (a limited liability company organized under the laws of Belgium with registered office at Generaal De Wittelaan Ll1 43, 2800 Mechelen, Belgium, registered with the Register of Legal Entities (Antwerp, division Mechelen) under the number 0466.460.429) (the "Company"),

to be held on Tuesday April29, 2025 at 2.00 p.m. (Belgian time) at the registered office of the Company,

and hereby notifies the Company of his/her/its intention to participate ¡n the Annual Shareholders' Meeting to be held on Tuesday April 29, 2025,

with the following securities:

	aandelen op naam en/of		registered shares and/or
	insch r'rjvi ngsrechten		subscription rights
(Aantal)		(Number)

(Datum ¡'Date)

(Naam / Nane)

(Handtekening / Signature)

De ondertekende kennisgeving dient uiterlijk op 23 april 2025 bij Galapagos NV toe te komen. Deze moet worden bezorgd per e-mail (shareholders@oloo.com) ofwel met de post (Galapagos NV, t.a.v. Annelies Denecker, Generaal De Wittelaan 111 43, 2800 Mechelen, België).

De ondergetekende is ermee uitdrukkelijk akkoord dat de Engelse vertaling van deze kennisgeving slechts een vrije vertaling is en enkel ter informatie, en dat de Nederlandse versie voorrang heeft op de Engelse versie

Aandeelhouders die willen stemmen per brief of zich willen laten vertegenwoordigen moeten ook voldoen aan de relevante voorwaarden zoals beschreven in de oproeping tot de Gewone Algemene Vergadering.

The signed notification must be received by Galapagos NV at the latest on April 23, 2025. It should be submitted by e-mail (shareholders@glpg.com) or by post (Galapagos NV, attn. Annelies Denecker, Generaal De Wittelaan 111 43, 2800 Mechelen, Belgium).

The undersigned expressly agrees that the English translation of the present notification is a free translation and for information purposes only, and that the Dutch version shall prevail over the English translation.

Shareholders who wish to vote by letter or which to be represented by proxy, must also comply with the relevant conditions as described in the convening notice to the Annual Shareholders' Meeting.

Galapagos NV I Kennisgevìng van deelname GAV 29 april 2025 | Attendance not¡fication AGM April 29, 2025

	Volmacht

(enkel te gebruiken door aandeelhouders)

Proxy

(to be used by shareholders only)

De ondergetekende: The undersigned

(Naant en adres / Name and address.)

hierin optredend als lastgever,

eigenaar van het volgende aantal aandelen in Galapagos NV (naamloze vennootschap naar Belgisch recht, met zetel te Generaal De Wittelaan 111 43, 2800 Mechelen, België, ingeschreven in het Rechtspersonenregister (RPR Antwerpen, afdeling Mechelen) onder het nummer 0466.460.429) (de "Vennootschap"):

herein acting as grantor of a proxy,

owner of the following number of shares in Galapagos NV (limited l¡ability company organized under the laws of Belgium, with registered office at Generaal De Wittelaan Ll1 43, 2800 Mechelen, Belgium, registered with the Register of Legal Entities (RLE Antwerp, division Mechelen) under the number 0466.460.429) (the "Company") :

(Aantal aandelen ,/ Number of shares.)

stelt hiermee aan tot z\n/haar bijzondere volmachtdrager, met recht van indeplaatsstelling:

herewith appoints as his/her special proxy holder, with the right of substitution:

Valeria Cnossen, General Counsel van/of Galapagos NV, p/a Generaal De Wittelaan Ll1 A3, 2800 Mechelen, België/Belgium (Alãam en adres van de gevolmachtigde / Name and address of the proxy holder)

hierna de "volmachtdrager",

aan wie hij/zij volmacht geeft tot b'tjwoning van, en uitoefen¡ng van de stemrechten tijdens de Gewone Algemene Vergadering van de Vennootschap die zal plaatsvinden op dinsdag 29 april 2025 om 14.00 uur (Belgische tijd) op de zetel van de Vennootschap, alsook elke andere aandeelhoudersvergadering met dezelfde agenda die daarna zou worden bijeengeroepen als gevolg van uitstel of verdaging, met als bedoeling de hierna uiteengezette agenda in overweg¡ng te nemen en om, voor dit doel, deel te nemen aan alle activiteiten, te stemmen of zich te onthouden, notulen en andere stukken te ondertekenen, woonplaats te kiezen, subdelegat¡e te geven, en meer in het algemeen te doen wat nuttig of noodzakel'rjk wordt geacht door de volmachtdrager.

Indien overeenkomstig arttkel 7:130 van het Wetboek van Vennootschappen en Verenigingen nieuw te behandelen onderwerpen op de agenda z¡jn opgenomen nadat onderhavige volmacht ter kennis van de Vennoobchap b gebracht, zal de volmachtdrager ook over deze nieuwe agendapunten kunnen stemmen voor zover de volmachtdrager daarbij geen ander belang dan het belang van ondergetekende aa ndeelhouder nastreeft.

Bij gebrek aan een specifieke steminstructie voor een bepaald agendapunt zal de volmachtdrager gerechtigd zijn "voor" het voorstel tot besluit te stemmen.

Deze volmacht is geen verzoek tot verlen¡ng van volmacht overeenkomstig de bepalÌngen van artikelen 7:144 of 7:145 van het Wetboek van Vennootschappen en Veren¡g¡ngen.

Deze volmacht dient handgeschreven of elektron¡sch te worden ondeftekend. Indien gebruik wordt gemaakt van de hereinafter the "proxy holder",

to whom he/she gives power of attorney to attend and exercise voting rights at the Annual Shareholders' Meeting of the Company to be held on Tuesday April 29, 2025 at 2:00 p.m. (Belgian time) at the registered office of the Company, as well as at any other shareholders' meeting with the same agenda that may be convened subsequently as a result of delay or adjournment, for the purpose of considering the agenda set forth below, and for this purpose, to take part ¡n all proceedings, to vote or abstain, to sign any m¡nutes and other items, to elect domicile, to sub-delegate authority, and more generally to do anything the proxy holder deems useful or necessary.

If pursuant to article 7:130 of the Eelgian Companies and Associations Code new items to be dealt with are included in the agenda after the present proxy form has been submitted to the Company, the proxy holder shall be entitled to vote on such new agenda items insofar as the proxy holder, by doing sq does not pursue another ìnterest than the interest of the undercigned shareholder.

If no specific vot¡ng instruct¡on is given for a specific item on the agenda, the proxy holder will be ent¡tled to vote "in favor" of the proposed resolution.

This proxy does not const¡tute an appl¡cat¡on for a power of attorney in accordance with the provisions ofafticles 7:144 or 7:145 of the Belgian Companies and Associations Code.

This proxy should be signed either in handwr¡ting or electronically. ff the opportun¡ty to sign this proxy form

Gewone Algemene vergader¡ng van 29 apr¡l 2025; Annual Shareholders' Meeting of April 29, 2025;

mogelijkheid om deze volmacht elektron¡sch te tekenen, dient het te gaan om een elektron¡sche handteken¡ng ¡n de zin van art¡kel 3.10 van Verordening (EU) Nr. 910/2014 van het Europees Parlement en de Raad van 23 jul¡ ²⁰¹⁴ betreffende elektronische identificatie en vertrouwensdiensten voor elektronische transact¡es ¡n de ¡nterne markt en tot Ìntrekk¡ng van R¡chtl¡jn 1999/93/EG, zoals gewijzigd van tijd tot t¡jd, of een gekwalificeerde elektronbche handtekening in de zin van art¡kel 3.12 van dezelfde Verordening.

electronically is made use ol ¡t must be an electronic signature within the mean¡ng of aft¡cle 3.10 of Regulation (EU) No 910/2014 of the European Parliament and of the Council of 23 July 2014 on electronic identifrcation and trust services for electronic transactions in the internal market and repealing Diredive 1999/93/EC as amended from time to t¡me, or a qual¡fìed eledronic s¡gnature w¡th¡n the meaning of article 3.12 of the same RegulatÌon.

Agenda

Gewone Al gemene Vergadering

1. Kennisname en bespreking van (a) het jaarverslag van de Raad van Bestuur betreffende de statutaire en geconsolideerde jaarrekening van de Vennootschap over het boekjaar afgesloten op 31 december 2024, en van (b) het verslag van de commissaris over de statutaire jaarrekening van de Vennootschap over het boekjaar afgesloten op 31 december 2024.

2. Kennisname en goedkeuring van de statutaire jaarrekening van de Vennootschap over het boekjaar afgesloten op 31 december 2024 en goedkeuring van de door de Raad van Bestuur voorgestelde bestemming van het jaarresultaat.

Voorstel van besluit: De algemene vergadering besluit de statuta¡re jaarrekening van de Vennootschap .over het boekjaar afgesloten op 31 december 2024, goed te keuren, alsmede de door de Raad van Bestuur voorgestelde bestemm¡ng van hetjaarresultaat goed te keuren.

Annual Shareholders' Meet¡ng

1. Acknowledgement and discussion of (a) the annual report ofthe Board of Directors in relation to the non-consolidated and consolidated annual accounts of the Company for the financial year ended on December 37,2024, and (b) the report of the statutory auditor in relation to the non-consolidated annual accounts of the Company for the financial year ended on December 3I,2024.

2. Acknowledgement and approval of the non-consol¡dated annual accounts of the Company for the financial year ended on December 31, 2024, and approval of the allocation of the annual result as proposed by the Board of Directors.

Proposed resolution: The shareholders' meet¡ng resolves to approve the non-consolidated annual accounts of the Company for the financ¡al year ended on December 31, 2024, and the allocation of the annual result as proposed by the Board of D¡rectors.

Agendapunt 2 - Stem¡nstruct¡e:	Agenda item 2 - Vot¡ng ¡nstruct¡onl
o	o	o
Voor / In favor	Tegen / Aga¡nst	Onthouding / Abstent¡on

1. Kennisname en bespreking van het verslag van de commissaris betreffende de geconsolideerde jaarrekening van de Vennootschap over het boekjaar afgesloten op 31 december 2024.

2. Kenn¡sname en bespreking van de geconsolideerde jaarrekening van de Vennootschap over het boekjaar afgesloten op 31 december 2024.

3. Kennisname en goedkeuring van het remuneratieverslag.

Voorstel van besluit: De algemene vergadering besluit om het remunerat¡everslag, opgenomen in hetjaarverslag van de Raad van Bestuur over het boekjaar afgesloten op 31 december 2024, goed te keuren.

1. Acknowledgement and d¡scussion of the report of the statutory auditor relating to the consolidated annual accounts of the Company for the financial year ended on December 31, 2024.

2. Acknowledgement and discussion of the conso¡idated annual accounts of the Company for thê financial year ended on December 3t,2024.

3. Acknowledgement and approval of the remunerat¡on report.

Proposed resolution: The shareholders' meeting resolves to approve the remunerat¡on report included in the annual report of the Board of Diredors for the frnancial year ended on December 31, 2024.

Agendapunt 5 - Steminstruct¡e		Agenda item 5 - Voting ¡nstruct¡on:
O	o	o
Voor / In favor	Tegen /Against	Onthouding / Abstention

1. Kwuting aan de (huidige en voormalige) leden van de Raad van Bestuur en de commissaris voor de uitoefening van hun respectievelijk mandaat uitgeoefend tijdens het boekjaar afgesloten op 31 december 2024.

2. Release from liability to be granted to the (current and former) members of the Board of Directors, and the statutory auditor for the performance of their respective mandates during the financial year ended on December 3L,2024.

Voorctel van besluít: De algemene vergader¡ng beslu¡t biJ' afzonderl¡jke stemm¡ng, om kwjting te geven aan elk (hu¡dig en voormalig) lid van de Raad van Bestuur, en aan de commlssaris voor alle aansprakel¡jkhe¡d voortvloeiend uit de uitoefening van hun respectieve mandaten gedurende het boekjaarafgesloten op 31 december 2024.

Proposed resol ution : The shareholders' meet¡ng resolveE by a separate vote, to release each (curent and former) member of the Board of Directors, and the statutory auditor from any liability arising from the performance of theÌr respective mandates during the frnancial year ended on December 31, 2024.

Agendapunt 6 - Stem¡nstruct¡e	Agenda item 6 - Voting instruction:
o	o	o
Voor / In favor	Tegen / Aga¡nst	Onthouding / Abstent¡on

1. Benoemlng van de heer Oleg Nodelman tot niet-uitvoerend bestuurder.

Reken¡ng houdend met de aanbeveling en het advies van het Benoemingscomité, beveelt de Raad van Bestuur aan de benoeming van de heer Oleg Nodelman als niet-uitvoerend bestuurder van de Vennootschap te bevestigen en voort te zetten voor een bijkomende termijn van vier jaar. In het bijzonder, heeft de Raad van Bestuur, op 6 oktober 2024, en met ingang vanaf 7 oktober 2024, de heer Oleg Nodelman benoemd tot niet-uitvoerend bestuurder van de Vennootschap door coöptat¡e naar aanleiding van het aftreden op 6 oktober 2O24 van de heer Daniel Baker, als onafhankelijk niet-uitvoerend bestuurder, die werd benoemd voor een termijn tot en met de afsluiting van de jaarlijkse aandeelhoudersvergadering die zal worden gehouden in 2026 en die zal hebben beslist over de jaarrekening voor het boekjaar afgesloten op 31 december 2025.

Voorctel van besluit: Op voorstel van de Raad van Bestuur, en ¡n overeenstemmtng met de aanbeveling en het advies van het Benoemingscom¡té, besluit de algemene vergaderÌng (a) de benoeming door coöptatie op 6 oktober 2024, en met ingang vanaf 7 oktober 2024, te bevestigen, volgend op het aftreden op 6 oktober 2024 van de heer Daniel Baker, de heer Oleg Nodelman te benoemen tot ntet-uitvoerend lid van de Raad van Bestuur van de Vennootschap, voor een brjkomende termijn van vier jaar, tot en met de afsluit¡ng van de jaarlijkse aandeelhoudersvergadering die zal worden gehouden in 2029, en die zal hebben besloten over de jaanekening voor het boekjaar eindigend op 31 december 2028. De algemene vergadering beslu¡t tevens dat het mandaat van de heer Oleg Nodelman onbezoldigd zal zijn.

1. Appo¡ntment of Mr. Oleg Nodelman as non-executive director.

Taking into account the recommendation and adv¡ce of the Nominat¡on Comm¡ttee, the Board of Directors recommends that the appointment of Mr. Oleg Nodelman as non-executive director of the Company be confirmed and continued for an additional term of four years. Notably, on October 6, 2024, and with effect as per October 7, 2024, the Board of Directors appointed Mr. Oleg Nodelman as non-executive director of the Company by co-optation following the resignation of Mr. Daniel Baker on October 6, 2024, as independent non-executive director, who was appointed for a term up to and including the closing of the annual shareholders' meeting to be held in 2026 which will have decided upon the financial statements for the financial year ended on December 31,2025.

Proposed resolution: Upon proposal of the Board of Directort and in accordance with the recommendation and advice of the Nomination Comm¡ttee, the shareholders'meet¡ng resolves (a) to confïrm the appointment by co-optation on Odober 6, 2024, and with effed as per Odober Z 2024, following the resignation of Mr. DanÌel Baker on October 6, 2024, and to appoint Mr. Oleg Nodelman as a non-executive member of the Board of Diredors of the Company, for an additional period of four years, up to and including the closing of the annual shareholders' meet¡ng to be held in 2029 wh¡ch will have decided upon the financial statements for the frnancial year ended on December 31, 2028. The shareholders'meeting also resolves that the mandate of Mr. Oleg Nodelman will not be remunerated.

Agendapunt 7 - Stem¡nstruct¡el	Agenda item 7 - Vot¡ng ¡nstruction:
o	o		o
Voor / In favor	Tegen / Against		Onthouding / Abstention

B. Bevestiging en benoeming van de commissaris met betrekking tot de "waarborging" van de CSRD du uzaamheidsverslaggeving.

voorstel van besluit In overeenstemm¡ng met de aanbeveling uan het Auditcomité en op voorstel van de Raad van Bestuur, en rekening houdend met het feit dat de Corporate Sustdinability Report¡ng Directive 2022/2464/EU ("CSRD\ ondertussen ¡s omgezet in het Belgisch recht, besluit de algemene vergadering (a) zoveel als nodig en vere¡st te bevest¡gen en bekrachtigen de beslissing van de aandeelhoudersvergadering, die voorafgaand aan de bovengenoemde omzetting van de CSRD heeft B. Confìrmation and appointment of the statutory auditor w¡th respect to the "assurance" of the CSRD susta¡nability report¡ng.

Proposed resolutíoni In accordance with the recommendation of the Audit Committee and upon proposal of the Board of Diredors, and taking ¡nto account that the Corporate Sustainability Report¡ng Diredive 2022/2464/EU ('CSRD) in the meantime has been transposed into Belgian ldw, the shareholders' meeting resolves (a) as far as needed and required, to confirm and ratit the decision by the annual general shareholderc' meet¡ng, which pr¡or to the aforementioned transpos¡t¡on of the CSRD took place on April

Galapagos NV I Volmacht GAV 29 april 2025 | Proxy AGM April 29, 2025 P.3ls

Gewone Algemene Vergader¡ng van 29 apr¡l 2025; Annual Shareholders' Meeting of Ap¡il 29,2O25i

Galápagos

plaatsgevonden op 30 apr¡l 2024, om de commissaris van de Vennootschap, zfinde BDO Bedrijfsrevisoren BV, met maatschappelijke zetel te Da Vincilaan 9/E.6, ¹⁹³⁰ Zaventem, en ingeschreven in de Kruispuntbank Ondernemingen (RPR Brussel, Nederlandstalige afdeling) onder het nummer 0431.088.289, vast vertegenwoordigd door Ellen Lombaerts, voor een termil'n van één jaar, te belasten met de waarborging van de duurzaamheidsverslaggeving van de Vennootschap, zoals bedoeld in de CSRD, voor het boekjaar dat afgesloten wordt op 31 december 2024 in overeenstemming met de toepasselijke wetgeving, (b) rekening houdend met het feit dat de bovengenoemde omzefiing van de CSRD ondertussen heeft plaaßgevonden, het bovengenoemde mandaat van BDO Bedr¡jfsrevisoren 8V te veilengen voor de waarborging van de duurzaamheidsverslaggeving van de Vennootschap, zoals bedoeld in artikelen 3:6/1 - 3:6/8 en artikelen 3:32/1 ' 3:32/6 van het Wetboek van Vennootschappen en Veren¡gingen voor een periode van één 1àar, om ook de waarborging van de duurzaamheidsverslaggeving van de Vennootschap voor het boekjaar eindigend op 31 december 2025 te omvatten, zodat (rekening houdend met de bepalingen van artikel 3:61, Ç8 van het Wetboek van Vennootschappen en Verenigingen) de eerste termijn van het wettelijk mandaat van de commissaris voor de waarborging van de duurzaamheidsverslaggeving van de Vennootschap in overeenstemming met de toepasselijke wetgeving wordt aþestemd op de huidige term¡jn van het wettelijk mandaat van de commissaris voor de controle van de jaarrekeningen van de Vennootschap (dat zal verstrijken onmiddellfk na gewone algemene vergadering van aandeelhouders die zal worden gehouden in 2026) en (c) de vergoeding van BDO Bedrijfsrevisoren BV voor deze waarborging uan de duurzaamheidsverslaggeving vast te stellen op EUR 80.000 (indien enige, exclusief BTW) voor het boekjaar eindigend op 31 december 2025. De aanstell¡ng van de commissaris met betrekking tot de voormelde waarborging zal vervallen onnÌddellijk na de gewone algemene vergadering van aandeelhouders die zal worden gehouden in 2026.

30, 2024, to charge the Company's statutory aud¡tor, being BDO Bedrijfsrevisoren BV w¡th its reg¡stered office at Da Vincilaan 9/8.6, 1930 Zaventem, and regirtered with the Crossroads Enterpr¡se Database (RPR Brusseþ Dutch-speakÌng division) under the number 0431.088.289, permanently represented by Ellen Lombaerts, for a per¡od of one year, with the assurance of the susta¡nab¡lity repoft¡ng of the Company, as referred to Ìn the CSRD for the financial year ending on December 31, 2024 in accordance with applÌcable law, (b) tak¡ng ¡nto account the aforement¡oned transpos¡t¡on of the CSRD that ¡n the meant¡me has taken place, to extend the aforementioned mandate of BDO Bedrijfsrevisoren BV for the assurance of the sustainability reporting of the Company, as referred to ¡n articles 3:6/1 - 3:6/8 and articles 3:32/1 - 3:32,/6 of the Belgian Compan¡es and Associat¡ons Code for a period of one year, to include also the assurance of the sustarnability reporting of the Company for the frnancial year endtng on December 31, 202, so that (taking into account the provisions of arttcle 3:61, 6B of the Belgian Companies and Assoc¡at¡ons Code) the first term of the statutory mandate of the statutory auditor for the assurance of the susta¡nability reporting of the Company in accordance with applicable law is aligned with the curent mandate of the statutory auditor to audit the Companyb annual Financial statement (which shall exphe immediately after the annual shareholders'meeting to be held in 2026), and (c) to determine the remunerat¡on of BDO Bedrijfsrev¡soren BV for the assurance of the Companyb sustainability reporting for the financial year ending on December 31, 2025 at EUR 80,000.00 (if any, VAT exclusive). The appointment of the statutory auditor with resped to the aforementioned assurance will expire ¡mmediately after the annual shareholders' meeting to be held Ìn 2026.

Agendapunt I - Steminstructie		Agenda item I - Vot¡ng instruct¡on:
o	o	t]
Voor / In favor	Tegen / Aga¡nst	Onthouding / Abstent¡on

Ondergetekende is er uitdrukkelijk mee akkoord dat: The undersigned expressly agrees that:

• (i) ingeval van afwezigheid van steminstructies voor enig agendapunt of in het geval dat er, om welke reden dan ook, enige onduidelijkheid zou ontstaan betreffende de steminstructies, de volmachtdrager altijd "voor" het voorstel tot besluit zal stemmen voor deze punten waarvoor geen of een onduidelijke steminstructie is gegeven, en dat dit een specifieke steminstructie geacht zal zijn in de zin van artikel 7:143, 54, 2o van het Wetboek van Vennootschappen en Verenigingen;

• (ii) de General Counsel als volmachtdrager (of, in voorkomend geval, de vervanger van de General Counsel) een aangestelde van Galapagos NV is en bijgevolg een potentieel belangenconflict heeft zoals bepaald in artikel 7:143, \$4 van het Wetboek van Vennootschappen en Verenig¡ngen. De General Counsel (of, in voorkomend geval, de vervanger van de General Counsel) zal enkel stemmen in uitvoering van de volmacht overeenkomstig de specifìeke steminstructies opgenomen in de volmacht; en

• (i) in the absence of voting instruct¡ons for any agenda item or in the event that, for any reason whatsoever, any uncertainty would arise with regards to the voting ¡nstructions, the proxy holder will always vote "in favor" of the proposal for such items for which no or an unclear voting instruction is given, and that this will be deemed to be a specific voting instruction in the sense of article 7:143, Ç4, 2o of the Belg¡an Companies and Associations Code;

• (¡i) the General Counsel as proxy holder (or, as the case may be, the General Counsel's substitute) is appointed by Galapagos NV and therefore has a potential conflict of interest as defined in article 7:143, 54 of the Belg¡an Companies and Associations Code. The General Counsel (or, as the case may be, the General Counsel's substitute) will only vote in execution of the proxy in accordance with the specific voting instructions included in the proxy; and

(iii) de Engelse vertaling van deze volmacht slechts een vr¡je vertaling is en uitsluitend ter informatie, en dat de Nederlandstalige versie voorrang heeft op de Engelse vertaling.

Onderhavige volmacht geldt tevens als aanmelding in de zin van artikel 7:134 van het Wetboek van Vennootschappen en Veren¡gingen.

Goed voor volmacht:

(ii¡) the English translation of this proxy is a free translation and for information purposes only, and that the Dutch version shall prevail over the English translation.

The present proxy shall also serve as notification within the meaning of article 7:734 oT the Belgian Companies and Assoc¡ations Code.

Good for proxy:

(Datum,/ Ddte) (Handteken ing / S¡gnature) (Naam / Name)

Het ondertekende volmachtformulier dient uiterlijk op 23 april 2025 toe te komen op de zetel van Galapagos NV. Het moet per e-mail (shareholders(ôglpg.com) of met de post (Galapagos NV, t.a.v. Annelies Denecker, Generaal De Wittelaan Ll1 43, 2800 Mechelen, België) bezorgd worden.

Aandeelhouders die zich wensen te laten vertegenwoord¡gen moeten ook aan de relevante voorwaarden voldoen zoals beschreven in de oproep¡ng tot de Gewone Algemene Vergadering.

The signed proxy form must be received at the latest on April 23, 2025 at the registered office of Galapagos NV. It should be submitted by e-mail (shareholders@glpg.com) or by post (Galapagos NV, attn. Annelies Denecker, Generaal De Wittelaan Ll1 43, 2800 Mechelen, Belgium).

Shareholders who wish to be represented by prory must also comply with the relevant conditions as described in the convening notice to the Annual Shareholders' Meet¡ng.

GATAPAGOS

Naamloze Vennootschap / Limited Liability Company Generaal De Wittelaan 111 A3, 2800 Mechelen, Belgium RPR / RLE Antwerp, division Mechelen 0466.460.429

Op 27 maart 2025 bedraagt het totaal aantal aandelen en stemrechten van Galapagos NV 65.897.O71,

On March 27, 2025, the total number of shares and voting rights of Galapagos NV amounts to 65ß97,O7L

#åeg ffiædæ&ræffiffi

Non-[xecutive Ncn-l ndependent Dii"ectoi'

Eoard of Dinectol's

Oleg Nodelman is the Founder and Portfolio Manager of EcoRl Capital LLC, a biotech-focused ínvestment advisory firm established in 2013, which invests in companies at all stages of research and development. With over twenty years of experience in biotech investing, Mr. Nodelman has expertise in allaspects of investment management and deep roots in the biotech and scientific communities. Before founding EcoRl, Mr. Nodelman was a portfolio manager at BVF Partners, one of the first hedge funds dedicated to investing in the biotechnology sector. He currently serves as a Board Member for two pubticly traded companies in addition to Galapagos NV: AnaptysBio (NASDAQ:ANAB), a cli n ica l-stage biotech nology com pa ny focused on deliveri ng in novative immunology therapeutics applicable to inflammatory and autoimmune ^diseases, a nd Zymeworks (NASDAQ: ZYM E), a clin ica [-sta ge biotech nology company developing a diverse pipetine of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to'treat diseases, including cancer, inflammation, and autoimmune disease. Mr. Nodelman has a Bachelor of Science in Foreign Service with a concentration in Science and Technology from Georgetown University.

www.bdo.be

The Corporate Vi[tage Da Vincilaan 9, Box E.6 Elsinore Buitding B-1 930 Zaventem

GALAPAGOS NV

Statutory auditor's report to the general meeting for the year ended 31 December 2OZ4

Free translation

BDO Bedrijfsrevisoren BV / BTW BE 0431.088.289 / RPR Brusset BDO Réviseurs d'Entreprises SRL i ryA BE 0431.088.289 / RPM Bruxetles

BDO Bedrijfsrevisoren - BDO Réviseurs d'Entreprises BV/5RL, a company under Belgian taw in the form of a private Limited tiabitity company, is a member of BDO lnternationat Limited, a UK company timited by guarantee, and forms part of the internationa[ BDO network of independent member firms. BDo is the brand name for the 8DO network and for each of the BDo lvlember Firms.

www.bdo.be

The Corporate ViItage Da Vincitaan 9, Box E.6 Etsinore Buitding B-1930 Zaventem

Free translation

STATUTORY AUDITOR'S REPORT TO THE GENERAL MEETING OF GALAPAGOS NV FOR THE YEAR ENDED 31 DECEMBER2024

ln the context of the statutory audit of the annual accounts of Gatapagos NV ("the Company"), we hereby present our statutory auditor's report. lt includes our report of the annual accounts and the other [ega[ and regutatory requirements. This report is an integrated whote and is indivisibte.

We have been appointed as statutory auditor by the general meeting of 25 Aprit 2023, fottowing the proposal formutated by the administrative body issued upon recommendation of the Audit Committee and upon presentation by the works councit. Our statutory auditor's mandate expires on the date of the general meeting deliberating on the annual accounts ctosed on 31 December 2024. We have performed the statutory audit of the annual accounts of the Company for two consecutive years.

REPORT ON THE ANNUAL ACCOUNTS Basis for unqualified opinion

Unqualified opinion

We have audited the annual accounts of the Company, which comprise the balance sheet as at 31 December 2024, the profit and loss account for the year then ended and the notes to the annual accounts, characterised by a batance sheet total of 4.044.144.044 EUR and a profit and loss account showing a profit for the year of 47.781.908 EUR.

ln our opinion, the annual accounts give a true and fair view of the Company's net equity and financial posítion as at 31 December 2024, as wetl as of its resutts for the year then ended, in accordance with the financial reporting framework appticabte in Betgium.

We conducted our audit in accordance with lnternational Standards on Auditing (lSAs) as appticabte in Belgium. Our responsibìlities under those standards are further described in the 'Statutory ouditor's responsibilities for the audit of the annual accounts'section in this report We have comptied with att the ethical requirements that are retevant to the audit of annual accounts in Betgium, including those concerning independence.

We have obtained from the administrative body and the offìcials of the Company the exptanations and information necessary for performing our audit.

We betieve that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

BDO Bedrijfsrevisoren BV / BTW BE 0431.088.289 / RPR Brussel BDO Réviseurs d'Entreprises SRL / TVA BE 0431.088.289 / RPM Bruxettes

BDO Bedrìjfsrevisoren - BDO Réviseurs d'Entreprises BV/SRL, a company under Belgian taw in the form of a private timited tiabitity company, is a member of BDO lnternational Limited, a uK company timited by guarantee, and forms part of the international BDO network of independent member firms. BDO is the brand name for the BDO network and for each of the BDO Member Firms.

Key audit matters

Key audit matters are those matters that, in our professional judgment, were of most significance in our audit of the annual accounts of the current year. These matters were addressed in the context of our audit of the annual accounts as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters.

Disposal of the Jyseleca@ business to Alfasigma

Key Audit lúatter Description

As described in note F-cap 6.19 of the annual accounts, on January 31,2024, lhe Company completed the sate of the Jyseteca@ business to Alfasigma and entered into a transition agreement with Atfasigma that specifies the responsibitities and services to be provided by both parties during a transition period fottowing the comptetion of the sate. On that date, the Company recognized a gain on disposal of 56,0 mEUR, an upfront cash receipt of 50,0 mEUR and a tiabitity related to a contribution for research and devetopment costs payabte to Alfasigma of 40,0 mEUR.

The accounting for the disposaI of the Jyseteca@ business to Alfasigma was identified as a key audit matter due to the judgement in identifying the different elements of the totaI consideration and accounting for the trans'ition agreement. Critical components of this transaction included identifying the assets and tiabitities transferred, the recognition of the R&D costs payabte to Atfasigma and determination of the gain on disposal of the Jyseteca@ business.

The audit of these components required significant auditor attention due to the transaction's magnitude, comptexity and significant financiaI impact.

How the Key Audit tulatter Was Addressed in the Audit

The primary procedures we performed to address this key audit matter inctuded:

• . Evatuatingmanagement's judgements over the identification of at[ assets and [iabitities betonging to the disposal of the Jyseteca@ business by reading retevant agreements and assessing the Company's ongoing involvement during the transition period agreed with Atfasigma.
• . Verifying the components included in the determinatìon of the gain on disposaI of the Jyseteca@ business, inctuding the identification of disposed off assets and [iabitities, the estimation of the enterprise value, the determination of the consideration received and recognition of contribution for R&,D costs payabte by the Company to Atfasigma.
• . Ensuring the accurate removal of the sold entities atong with theìr respective assets and tiabitities from the books.
• . Verifying the correct presentation of the gain on disposal of the Jyseleca@ business and the associated transition services in the annual accounts.

Valuation of investments in subsidiaries, related intangibles assets and receivables

Key Audit lvlatter Description

As described in notes F-cap 6.2.3, F-cap 6.4.1 and F-cap 6.15 of the annual accounts, Galapagos reports intangible assets totaling109,1 mEUR, investments of 198,3 mEUR and intercompany receivabtes of '100,3 mEUR. The Company conducted an impairment test on its investments in subsidiaries, atong with the retated intangible assets and receivabtes at December 31,2024.

The impairment test is conducted by anatogy with the impairment test on the CAR-T/Cett therapy cash generating unit at consolidated [eve[, using a discounted cash flow model to determine its fair vatue less cost of disposat.

Auditing the Company's impairment tests for its investments in subsidiaries, along with the related intangible assets and receivabtes was complex and required a high degree of judgment, largely due to the significant estimations needed to determine the fair value less cost to se[[, of the cash-generating unit CAR-T/Cett therapy. The fair value estimates are specifìcatty based on assumptions tailored to CAR-T research and devetopment activities and its product candidates. These assumptions criticatty impact the significant uncertaìnty involved in reaching cIinicaI devetopment mitestones. Essentia[ factors, such as the timing of anticipated future cash ftows, long-term sates projections that inctude patient volumes, market share, pricing, and the discount rate, are pivotal to these estimates.

The impairment of investments in subsidiaries, their related intangìbles assets and receivabtes, is identified as a key audit matter due to the vatuatìon methodology necessitating the Company to appty significant estimates and assumptions specific to the CAR-T/Cett therapy business. This process demands extensive audit efforts, inctuding the engagement of professionals with speciatized skitls.

How the Key Audit lvlatter Was Addressed in the Audit

The prìmary procedures we performed to address this key audit matter included:

¡ Critical[y evaluating and chattenging the design and operating effectiveness of the Company's internaI controts retated to the impairment of

investments in subsidiaries, intangibles assets and receivables.

• Assessing the appropriateness of the vatuation methodology used by the Company to estimate the fair vatue less cost of disposal of the CAR-T/Cett Therapy cashgenerating unit which was used by analogy to verify for possible impairment. a
• Scrutinizíng the key assumptions and estimates used by the Company, such as projected cash flows, discount rates, and probabitity of success of achieving ctinical devetopment milestones. We compared these assumptions with industry reports to assess their reasonabteness and consìstency with externa[ market conditions. a
• ^Invotving professionats with expertise in financial vatuation to provide an independent evatuation of discount rate used. a
• Examining the sensitivity anatyses performed by the Company to understand the impact of changes in key assumptions on the impairment assessment and performing our own sensitivity checks. a
• Verifying the approprìateness and compteteness of the valuation disclosures in the annual accounts. a

Responsibilities of admìnistrative body for the draftìng of the annual accounts

The administrative body is responsible for the preparation of annual accounts that give a true and fair view in accordance with the financial reporting framework appticabte in Betgium, and for such internal control as the administrative body determines is necessary to enabte the preparation of annual accounts that are free from materia[ misstatement, whether due to fraud or error.

ln preparing the annual accounts, the administrative body is responsible for assessing the Company's abitity to continue as a going concern, disctosing, as appticabte, matters retated to goìng concern and using the going concern basis of accounting untess the administrative body either intends to tiquidate the Company or to cease operations, or has no reatistic atternative but to do so.

Statutory auditor's responsibilities for the audit of the annual accounts

Our objectives are to obtain reasonable assurance about whether the annual accounts as a whote are free from material misstatement, whether due to fraud or error, and to jssue a statutory auditor's report that inctudes our opinion. Reasonable assurance is a high [eve[ of assurance, but is not a guarantee that an audit conducted in accordance with lSAs witl atways detect a material misstatement when it exists.

Misstatements can arise from fraud or error and are considered material if, individuatty or in the aggregate, they could reasonabty be expected to inftuence the economic decisions of users taken on the basis of these annual accounts.

When executing our audit, we respect the [ega[, regulatory and normative framework appticabte for the audit of annuaI accounts in Belgium. However, a statutory audit does not guarantee the future viabitity of the Company, neither the efficiency and effectiveness of the management of the Company by the administrative body. Our responsibitities with respect to the administrative body's use of the going concern basis of accounting are described betow.

As part of an audit in accordance with lSAs, we exercise professionat judgment and maintain professional skepticism throughout the audit. We also:

• . ldentify and assess the risks of material misstatement of the annual accounts, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a materiaI misstatement resulting from fraud is higher than for one resulting from error, as fraud may invotve coltusion, forgery, intentional omìssions, misrepresentations, or the override of internaI controt;
• . Obtain an understanding of internaI control retevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company's internaI control;
• . Evatuate the appropriateness of accounting poticies used and the reasonabteness of accounting estimates and related disctosures made by the administrative body;
• Conctude on the appropriateness of the administrative body's use of the going concern basis of accounting and, based on the audit evidence obtained, whether a material uncertainty exists retated to events or conditions that may cast sìgnificant doubt on the Company's abitity to continue as a going concern. lf we conctude that a material uncertainty exists, we are required to draw attention in our statutory auditor's report to the retated disclosures in the annual accounts or, if such disclosures are inadequate, to modify our opinion.

Our conctusions are based on the audit evidence obtained up to the date of our statutory auditor's report. However, future events or conditions may cause the Company to cease to iontinue as ^a going concern;

. Evatuate the overatI presentation, structure and content of the annual accounts and whether the annuaI accounts represent the undertying transactions and events in a manner that achieves fair presentation.

We communicate with the Áudit Committee regarding, among other matters, the ptanned scope and timing of the audit and significant audit findings, inctuding any significant deficiencies in internal control that we identified during our audit.

We atso provide the Audit Committee with a statement that we have comptied with retevant ethical requirements regardìng independence, and to communicate with them alt retationships and other matters that may reasonabty be thought to bear on our independence and, where applicable, related safeguards.

From the matters communicated with the Audit Committee, we determine those matters that were of most significance in the audit of the financial statements of the current year, and are therefore the key audit matters. We describe these matters in our statutory auditor's report, unless law or regulation precludes pubtic disctosure about the matter.

OTHER LEGAL AND REGULATORY REQUIREMENTS

Responsibi Iities of the administrative body

The administrative body is responsible for the preparation and the content of the director's report, inctuding the sustainabitity information and of the other information inctuded in the annuaI report, for the preparation and content of the documents to be deposited in accordance with the legal and regulatory requirements, as well as for the comptiance with the [egal and regulatory requirements regardìng bookkeeping, with the Code of companies and associations and with the Company's by-taws.

Responsíbìlities of the statutory auditor

ln the context of our mission and in accordance with the Belgian standard (revised draft 2025) which is complementary to the lnternational Standards on Auditing (lSAs) as appticabte in Betgium, it is our responsibitity to verify, in a[[ material aspects, the director's report and the other information inctuded in the annual report, certain documents to be deposited in accordance with the [ega[ and regutatory requirements, and comptiance with certain provisions of the Code of companies and associations and of the Company's by-taws, and to report on these etements.

Aspects related to the director's report and to the other informatíon ìncluded in the annual report over the annual accounts

The director's report contains the sustainability information subject of our separate report concerning the timited assurance on this sustainabitity information.

This section does not concern the assurance on the sustainability information inctuded in the director's report. For this part of the director's report, we refer to our separate report on this matter.

ln our opinion, after having performed specific procedures in relation to the director's report, the director's report is consistent with the annual accounts for the same financial year, and it is prepared in accordance with artictes 3:5 and 3:6 of the Code of companies and associations.

ln the context of our audit of the annual accounts, we are also responsibte for considering, in particutar based on the knowtedge we have obtained during the audit, whether the director's report and the other informat'ion inctuded in the annual report, contain a material misstatement, i.e. information which is inadequatety disclosed or otherwise mìsteading. Based on the procedures we have performed, there are no material misstatements we have to report to you.

Statement related to the social balance sheet

The social balance sheet, to be deposited at the NationaI Bank of Betgium in accordance with article 3:12, 51, 8' of the Code of companies and associations, inctudes, both in terms of form and content, the information required by the said Code, inctuding that relating to information on wages and training and does not present any material inconsistencies with the information that we have at our disposition during the performance of our mission.

Stdtement related to independence

• . Our audit firm and our network did not provide seryices which are incompatibte with the statutory audìt of annual accounts and our audit firm remained independent of the Company during the terms of our mandate.
• . The fees related to additional services which are compatible with the statutory audit of annuat accounts as referred to in article 3:65 of the Code of companies and associations, were duly itemised and vatued in the notes to the annual accounts.

Other statements

• . Without prejudice to certain formal aspects of minor importance, the accounting records are maintained in accordance with the [ega[ and regulatory requirements appticabte in Betgium.
• . The appropriation of results proposed to the generaI meeting complies with the [ega[ provisions and the Company's by-Iaws.
• We do not have to report to you any transactions undertaken or decisions taken in breach of the by-laws or the Code of companies and associations except for the fact that the annual accounts and the consotidated annual accounts as at 31 December 2023 were not fited within the period stipulated in the Code of companies and associations.
• This report is in comptiance with the contents of our additional report to the Audit Committee as referred to in articte 11 of regutation (EU) No 537 /2014.

GALÀPAGOs NV:

Statutory auditor's report to the generat meeting of the company on the annuat accounts for the year ended 31 December 2024

We have assessed the pecuniary consequences for the Company of the decisions retated to the conftict of interests as described in the conctusions of the administrative body and having nothing to report to you.

Zaventem, 27 March2025

BDO Bedrijfsrevisoren BV Statutory auditor Represented by Etten Lombaerts. Auditor -Acting for a company