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FENNEC PHARMACEUTICALS INC. Director's Dealing 2010

May 10, 2010

35599_dirs_2010-05-10_4ed05918-d7fa-4d13-9a16-b30772fbbfd8.zip

Director's Dealing

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SEC Form 4/A — Form 4/A

Issuer: ADHEREX TECHNOLOGIES INC (AHX)
CIK: 0001211583
Period of Report: 2010-02-21

Reporting Person: Southpoint Capital Advisors LP (10% Owner)
Reporting Person: Southpoint Capital Advisors LLC (10% Owner)
Reporting Person: Southpoint GP, LP (10% Owner)
Reporting Person: Southpoint GP, LLC (10% Owner)
Reporting Person: Clark John Smith II (10% Owner)

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2010-02-21 Common Stock Warrants (right to buy) $ J 0 Disposed 2010-02-21 Common Stock (20752000) Indirect

Footnotes

F1: On February 23, 2010 the reporting persons filed a Form 4, which was incorrectly designated as a Form 4/A, to report the expiration on February 21, 2010 of warrants to purchase 20,752,000 shares of common stock issued by Adherex Technologies Inc. The expiration of the warrants was exempted by Rules 16b-6(d) and 16a-4(d), and such filing was voluntary, since none of the reporting persons received any value as a result of the expiration of the warrants.

F2: Southpoint Capital Advisors LP, and its general partner Southpoint Capital Advisors LLC, held the reported securities indirectly on behalf of Southpoint Fund LP, Southpoint Qualified Fund LP, Southpoint Master Fund, LP and Southpoint Offshore Fund, Ltd., for which Southpoint Capital Advisors LP serves as investment manager. Southpoint GP, LP, and its general partner Southpoint GP, LLC, held the reported securities indirectly on behalf of Southpoint Fund LP, Southpoint Qualified Fund LP, and Southpoint Master Fund, LP, of which Southpoint GP, LP is the general partner. John S. Clark II reports the securities held indirectly by Southpoint GP, LLC and Southpoint Capital Advisors LLC as the manager of each.

F3: Each of the reporting persons disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein, and this report shall not be deemed an admission that such reporting person was the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.