EXELIXIS, INC. — Director's Dealing 2025

Feb 27, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-02-24

Reporting Person: Senner Christopher J. (EVP and CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-02-24	Common Stock	M	29314	$18.80	Acquired	808921	Direct
2025-02-24	Common Stock	S	29314	$36.14	Disposed	779607	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-02-24	Option (right to buy)	$18.80	M	29314	Disposed	2025-09-09	Common Stock (29314)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	2723	Indirect

Footnotes

F1: Includes 266,700 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic
equivalent of one share of Common Stock.

F2: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $36.11 to $36.21. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 2 to this Form 4.

F3: Represents shares of Common Stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of February 24, 2025.

F4: The option, representing the right to purchase a total of 129,314 shares of Common Stock, became fully exercisable on September 10, 2022.