EXELIXIS, INC. — Director's Dealing 2025

Mar 1, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-02-27

Reporting Person: Smith Julie (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-02-27	Common Stock	M	31167	$20.50	Acquired	41945	Direct
2025-02-27	Common Stock	M	23347	$19.77	Acquired	65292	Direct
2025-02-27	Common Stock	S	54514	$38.13	Disposed	10778	Direct
2025-02-28	Common Stock	M	19294	$19.77	Acquired	30072	Direct
2025-02-28	Common Stock	S	19294	$37.62	Disposed	10778	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-02-27	Option (right to buy)	$20.50	M	31167	Disposed	2025-05-23	Common Stock (31167)	Direct
2025-02-27	Option (right to buy)	$19.77	M	23347	Disposed	2026-05-22	Common Stock (23347)	Direct
2025-02-28	Option (right to buy)	$19.77	M	19294	Disposed	2026-05-22	Common Stock (19294)	Direct

Footnotes

F1: Includes 10,015 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic
equivalent of one share of Common Stock.

F2: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $37.75 to $38.37. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 2 to this Form 4.

F3: The option, representing the right to purchase a total of 31,167 shares of Common Stock, became fully exercisable on May 24, 2018.

F4: The option, representing the right to purchase a total of 42,641 shares of Common Stock, became fully exercisable on May 23, 2019.