EXELIXIS, INC. — Director's Dealing 2025

May 17, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-05-15

Reporting Person: PAPADOPOULOS STELIOS (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-05-15	Common Stock	M	20634	$19.77	Acquired	1300050	Direct
2025-05-15	Common Stock	S	20634	$44.35	Disposed	1279416	Direct
2025-05-15	Common Stock	M	15874	$20.50	Acquired	1295290	Direct
2025-05-15	Common Stock	S	15874	$44.35	Disposed	1279416	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-05-15	Option (right to buy)	$19.77	M	20634	Disposed	2026-05-22	Common Stock (20634)	Direct
2025-05-15	Option (right to buy)	$20.50	M	15874	Disposed	2025-05-23	Common Stock (15874)	Direct

Footnotes

F1: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic
equivalent of one share of Common Stock.

F2: The option, representing the right to purchase a total of 20,634 shares of Common Stock, became fully exercisable on May 23, 2019.

F3: The option, representing the right to purchase a total of 15,874 shares of Common Stock, became fully exercisable on May 24, 2018.