EXELIXIS, INC. — Director's Dealing 2025

May 17, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-05-15

Reporting Person: Senner Christopher J. (EVP and CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-05-15	Common Stock	F	41422	$44.65	Disposed	967842	Direct
2025-05-16	Common Stock	M	100000	$18.80	Acquired	1067842	Direct
2025-05-16	Common Stock	S	100000	$46	Disposed	967842	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-05-16	Option (right to buy)	$18.80	M	100000	Disposed	2025-09-09	Common Stock (100000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	2723	Indirect

Footnotes

F1: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2: Includes 419,440 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

F3: Represents shares of Common Stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of May 14, 2025.

F4: The option, representing the right to purchase a total of 100,000 shares of Common Stock, became fully exercisable on September 10, 2022.